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Clinical Characteri...
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Janzing, Anna MUniversity Medical Center Groningen
(författare)
Clinical Characteristics Suggestive of a Genetic Cause in Cerebral Palsy : A Systematic Review
- Artikel/kapitelEngelska2024
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LIBRIS-ID:oai:lup.lub.lu.se:766e837f-1f86-46aa-9539-97f660ea568c
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https://lup.lub.lu.se/record/766e837f-1f86-46aa-9539-97f660ea568cURI
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https://doi.org/10.1016/j.pediatrneurol.2024.01.025DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:for swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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BACKGROUND: Cerebral palsy (CP) is a clinical diagnosis and was long categorized as an acquired disorder, but more and more genetic etiologies are being identified. This review aims to identify the clinical characteristics that are associated with genetic CP to aid clinicians in selecting candidates for genetic testing.METHODS: The PubMed database was systematically searched to identify genes associated with CP. The clinical characteristics accompanying these genetic forms of CP were compared with published data of large CP populations resulting in the identification of potential indicators of genetic CP.RESULLTS: Of 1930 articles retrieved, 134 were included. In these, 55 CP genes (described in two or more cases, n = 272) and 79 candidate genes (described in only one case) were reported. The most frequently CP-associated genes were PLP1 (21 cases), ARG1 (17 cases), and CTNNB1 (13 cases). Dyskinesia and the absence of spasticity were identified as strong potential indicators of genetic CP. Presence of intellectual disability, no preterm birth, and no unilateral distribution of symptoms were classified as moderate genetic indicators.CONCLUSIONS: Genetic causes of CP are increasingly identified. The clinical characteristics associated with genetic CP can aid clinicians regarding to which individual with CP to offer genetic testing. The identified potential genetic indicators need to be validated in large CP cohorts but can provide the first step toward a diagnostic algorithm for genetic CP.
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Eklund, ErikLund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund(Swepub:lu)medk-eek
(författare)
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De Koning, Tom JLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,University Medical Center Groningen(Swepub:lu)to2856jd
(författare)
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Eggink, HendriekjeUniversity of Groningen
(författare)
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University Medical Center GroningenEpilepsicentrum
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Pediatric Neurology153, s. 144-1510887-8994
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