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- Kanje, MartinLund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science (author)
The effect of gossypol on fast axonal transport and microtubule assembly
- Article/chapterEnglish1986
Publisher, publication year, extent ...
- Elsevier BV,1986
- 6 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:7678f1fb-3db8-4df1-aab0-ae66e6f20246
- https://lup.lub.lu.se/record/7678f1fb-3db8-4df1-aab0-ae66e6f20246URI
- https://doi.org/10.1016/0005-2736(86)90134-3DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Gossypol at micromolar concentrations (2 μM) was found to inhibit axonal transport and a microsomal ATPase activity in the frog sciatic nerve, although axonal microtubules and the neuronal content of AMP, ADP and ATP were not affected. At slightly higher concentrations (30-40 μM), gossypol also inhibited microtubule assembly and neuronal energy metabolism. Gossypol accumulated in the nerve and the results indicate that gossypol may act as a potent neurotoxin.
Subject headings and genre
- NATURVETENSKAP Biologi Cellbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
- Axonal transport
- Gossypol
- Microtubule assembly
Added entries (persons, corporate bodies, meetings, titles ...)
- Ekström, PerLund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science(Swepub:lu)zoof-pek (author)
- Deinum, JohannaUniversity of Gothenburg (author)
- Wallin, MargaretaUniversity of Gothenburg (author)
- Biologiska institutionenNaturvetenskapliga fakulteten (creator_code:org_t)
Related titles
- In:Biochimica et Biophysica Acta - Biomembranes: Elsevier BV856:3, s. 437-4420005-2736
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