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  • Spencer, RebeccaUniversity College London (author)

EVERREST prospective study : A 6-year prospective study to define the clinical and biological characteristics of pregnancies affected by severe early onset fetal growth restriction

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-01-23
  • Springer Science and Business Media LLC,2017

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:76bd1177-0b32-44d9-b9c7-db1d91eb8876
  • https://lup.lub.lu.se/record/76bd1177-0b32-44d9-b9c7-db1d91eb8876URI
  • https://doi.org/10.1186/s12884-017-1226-7DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Fetal growth restriction (FGR) is a serious obstetric condition for which there is currently no treatment. The EVERREST Prospective Study has been designed to characterise the natural history of pregnancies affected by severe early onset FGR and establish a well phenotyped bio-bank. The findings will provide up-to-date information for clinicians and patients and inform the design and conduct of the EVERREST Clinical Trial: a phase I/IIa trial to assess the safety and efficacy of maternal vascular endothelial growth factor (VEGF) gene therapy in severe early onset FGR. Data and samples from the EVERREST Prospective Study will be used to identify ultrasound and/or biochemical markers of prognosis in pregnancies with an estimated fetal weight (EFW) <3rd centile between 20+0 and 26+6 weeks of gestation. Methods: This is a 6 year European multicentre prospective cohort study, recruiting women with a singleton pregnancy where the EFW is <3rd centile for gestational age and <600 g at 20+0 to 26+6 weeks of gestation. Detailed data are collected on: maternal history; antenatal, peripartum, and postnatal maternal complications; health economic impact; psychological impact; neonatal condition, progress and complications; and infant growth and neurodevelopment to 2 years of corrected age in surviving infants. Standardised longitudinal ultrasound measurements are performed, including: fetal biometry; uterine artery, umbilical artery, middle cerebral artery, and ductus venosus Doppler velocimetry; and uterine artery and umbilical vein volume blood flow. Samples of maternal blood and urine, amniotic fluid (if amniocentesis performed), placenta, umbilical cord blood, and placental bed (if caesarean delivery performed) are collected for bio-banking. An initial analysis of maternal blood samples at enrolment is planned to identify biochemical markers that are predictors for fetal or neonatal death. Discussion: The findings of the EVERREST Prospective Study will support the development of a novel therapy for severe early onset FGR by describing in detail the natural history of the disease and by identifying women whose pregnancies have the poorest outcomes, in whom a therapy might be most advantageous. The findings will also enable better counselling of couples with affected pregnancies, and provide a valuable resource for future research into the causes of FGR. Trial registration:NCT02097667registered 31st October 2013.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ambler, GarethUniversity College London (author)
  • Brodszki, JanaLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)gyn-jko (author)
  • Diemert, AnkeUniversity Medical Center Hamburg-Eppendorf (author)
  • Figueras, FrancescUniversity of Barcelona (author)
  • Gratacós, EduardUniversity of Barcelona (author)
  • Hansson, Stefan R.Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)gyn-sha (author)
  • Hecher, KurtUniversity Medical Center Hamburg-Eppendorf (author)
  • Huertas-Ceballos, AngelaUniversity College London (author)
  • Marlow, NeilUniversity College London (author)
  • Marsál, KarelLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)gyn-kma (author)
  • Morsing, EvaLund University,Lunds universitet,Neonatologi,Forskargrupper vid Lunds universitet,Neonatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-emg (author)
  • Peebles, DonaldUniversity College London (author)
  • Rossi, CarloMagnus Life Science (author)
  • Sebire, Neil J.Great Ormond Street Hospital (author)
  • Timms, John F.University College London (author)
  • David, Anna L.University College London (author)
  • University College LondonObstetrik och gynekologi, Lund (creator_code:org_t)
  • EVERREST Consortium

Related titles

  • In:BMC Pregnancy and Childbirth: Springer Science and Business Media LLC17:11471-2393

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