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Risk-adjusted bench...
Risk-adjusted benchmarking of long-term overall survival in patients with HER2-positive early-stage Breast cancer : A Swedish retrospective cohort study
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- Thurell, Jacob (författare)
- Karolinska Institute,Karolinska University Hospital
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- Manouchehri, Narges (författare)
- Karolinska Institute
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- Fredriksson, Irma (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Wilking, Ulla (författare)
- Karolinska Institute
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- Bergh, Jonas (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Ryden, Lisa (författare)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancerkirurgi,Forskargrupper vid Lunds universitet,The Liquid Biopsy och Tumörprogression i Bröstcancer,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröstcancerbehandling,Sektion I,Institutionen för kliniska vetenskaper, Lund,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Breast Cancer Surgery,Lund University Research Groups,The Liquid Biopsy and Tumor Progression in Breast Cancer,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast cancer treatment,Section I,Department of Clinical Sciences, Lund,Skåne University Hospital
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- Koppert, Linetta B. (författare)
- Erasmus University Medical Center
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- Karsten, Maria M. (författare)
- Charité - University Medicine Berlin
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- Kiani, Narsis A. (författare)
- Karolinska Institutet,Karolinska Institute
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- Hedayati, Elham (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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(creator_code:org_t)
- 2023
- 2023
- Engelska 7 s.
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Ingår i: Breast. - 0960-9776. ; 70, s. 18-24
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aim: The main objective of the current study was to explore the value of risk-adjustment when comparing (i.e. benchmarking) long-term overall survival (OS) in breast cancer (BC) between Swedish regions. We performed risk-adjusted benchmarking of 5- and 10-year OS after HER2-positive early BC diagnosis between Sweden's two largest healthcare regions, constituting approximately a third of the total population in Sweden. Methods: All patients diagnosed with HER2-positive early-stage BC between 01-01–2009 and 31-12-2016 in healthcare regions Stockholm-Gotland and Skane were included in the study. Cox proportional hazards model was used for risk-adjustment. Unadjusted (i.e. crude) and adjusted 5- and 10-year OS was benchmarked between the two regions. Results: The crude 5-year OS was 90.3% in the Stockholm-Gotland region and 87.8% in the Skane region. The crude 10-year OS was 81.7% in the Stockholm-Gotland region and 77.3% in the Skane region. However, when adjusted for age, menopausal status and tumour biology, there was no significant OS disparity between the regions, neither at the 5-year nor 10-year follow-up. Conclusion: This study showed that risk-adjustment is relevant when benchmarking OS in BC, even when comparing regions from the same country that share the same national treatment guidelines. This is, to our knowledge, the first published risk-adjusted benchmarking of OS in HER2-positive BC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast neoplasm
- Databases
- Factual/statistics and numerical data
- Female
- Quality improvement
- Risk factor
- Survival analysis
- Survival rate
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Thurell, Jacob
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Manouchehri, Nar ...
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Fredriksson, Irm ...
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Wilking, Ulla
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Bergh, Jonas
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Ryden, Lisa
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Koppert, Linetta ...
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Karsten, Maria M ...
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Kiani, Narsis A.
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Hedayati, Elham
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Breast
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Breast (Edinburg ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet