A group B Streptococcus alpha-like protein subunit vaccine induces functionally active antibodies in humans targeting homotypic and heterotypic strains

Pawlowski, AndrzejLund University,Lunds universitet,Adaptivt immunförsvar,Forskargrupper vid Lunds universitet,Adaptive Immunity,Lund University Research Groups (author)

Maternal vaccination is a promising strategy for preventing neonatal disease caused by group B Streptococcus. The safety and immunogenicity of the prototype vaccine GBS-NN, a fusion protein consisting of the N-terminal domains of the alpha-like proteins (Alp) αC and Rib, were recently evaluated favorably in healthy adult women in a phase 1 trial. Here we demonstrate robust immunoglobulin G (IgG) and immunoglobulin A (IgA) responses against αC and Rib, as well as against the heterotypic Alp family members Alp1–Alp3. IgA and heterotypic IgG responses are more variable between subjects and correlate with pre-existing immunity. Vaccine-induced IgG mediates opsonophagocytic killing and prevents bacterial invasion of epithelial cells. Like the vaccine-induced response, naturally acquired IgG against the vaccine domains is dominated by IgG1. Consistent with the high IgG1 cross-placental transfer rate, naturally acquired IgG against both domains reaches higher concentrations in neonatal than maternal blood, as assessed in a separate group of non-vaccinated pregnant women and their babies.

Lannergård, JonasLund University,Lunds universitet,Adaptivt immunförsvar,Forskargrupper vid Lunds universitet,Adaptive Immunity,Lund University Research Groups(Swepub:lu)med-jlg (author)
Gonzalez-Miro, MajelaLund University,Lunds universitet,Adaptivt immunförsvar,Forskargrupper vid Lunds universitet,Adaptive Immunity,Lund University Research Groups(Swepub:lu)ma2084go (author)
Cao, DuojiaLund University,Lunds universitet,Adaptivt immunförsvar,Forskargrupper vid Lunds universitet,Adaptive Immunity,Lund University Research Groups(Swepub:lu)med-djc (author)
Larsson, SaraLund University,Lunds universitet,Adaptivt immunförsvar,Forskargrupper vid Lunds universitet,Adaptive Immunity,Lund University Research Groups(Swepub:lu)medk-sla (author)
Persson, Jenny J.Lund University,Lunds universitet,Värd-patogeninteraktioner,Forskargrupper vid Lunds universitet,Host-Pathogen Interactions,Lund University Research Groups(Swepub:lu)mmb-jpe (author)
Kitson, GeoffMinervaX ApS (author)
Darsley, MichaelMinervaX ApS (author)
Rom, Ane LilleøreCopenhagen University Hospital (author)
Hedegaard, MortenCopenhagen University Hospital (author)
Fischer, Per B.MinervaX ApS (author)
Johansson-Lindbom, BengtLund University,Lunds universitet,Adaptivt immunförsvar,Forskargrupper vid Lunds universitet,Adaptive Immunity,Lund University Research Groups,MinervaX ApS(Swepub:lu)immt-bjo (author)
Adaptivt immunförsvarForskargrupper vid Lunds universitet (creator_code:org_t)

By the author/editor: Pawlowski, Andrz ...; Lannergård, Jona ...; Gonzalez-Miro, M ...; Cao, Duojia; Larsson, Sara; Persson, Jenny J ...; show more...; Kitson, Geoff; Darsley, Michael; Rom, Ane Lilleør ...; Hedegaard, Morte ...; Fischer, Per B.; Johansson-Lindbo ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

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