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Psychosis in System...
Psychosis in Systemic Lupus Erythematosus : Results From an International Inception Cohort Study
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- Hanly, John G. (author)
- Dalhousie University
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- Li, Qiuju (author)
- University of Cambridge
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- Su, Li (author)
- University of Cambridge
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- Urowitz, Murray B. (author)
- University of Toronto
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- Gordon, Caroline (author)
- University of Birmingham
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- Bae, Sang Cheol (author)
- Hanyang University
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- Romero-Diaz, Juanita (author)
- Instituto Nacional de Ciencias Médicas y Nutrición
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- Sanchez-Guerrero, Jorge (author)
- University of Toronto
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- Bernatsky, Sasha (author)
- McGill University
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- Clarke, Ann E. (author)
- University of Calgary
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- Wallace, Daniel J. (author)
- Jonsson Comprehensive Cancer Center
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- Isenberg, David A. (author)
- University College London,Indian Institute of Technology
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- Rahman, Anisur (author)
- University College London
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- Merrill, Joan T. (author)
- Oklahoma Medical Research Foundation
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- Fortin, Paul R. (author)
- Laval University
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- Gladman, Dafna D. (author)
- University of Toronto
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- Bruce, Ian N. (author)
- Christie NHS Foundation Trust
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- Petri, Michelle (author)
- Johns Hopkins University School of Medicine
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- Ginzler, Ellen M (author)
- SUNY Downstate Health Sciences University,Feinstein Institute for Medical Research
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- Dooley, M. A. (author)
- University of North Carolina
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- Steinsson, Kristjan (author)
- National University Hospital of Iceland
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- Ramsey-Goldman, Rosalind (author)
- Northwestern University
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- Zoma, Asad A. (author)
- Hairmyres Hospital
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- Manzi, Susan (author)
- Allegheny Health Network
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- Nived, Ola (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jonsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Khamashta, Munther A. (author)
- Guy's and St Thomas' NHS Foundation Trust
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- Alarcón, Graciela S. (author)
- University of Alabama
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- van Vollenhoven, Ronald F. (author)
- Karolinska Institutet,Karolinska Institute
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- Aranow, Cynthia (author)
- Feinstein Institute for Medical Research
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- Mackay, Meggan (author)
- Feinstein Institute for Medical Research
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- Ruiz-Irastorza, Guillermo (author)
- University of the Basque Country
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- Ramos-Casals, Manuel (author)
- Hospital Clínic of Barcelona
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- Lim, S. Sam (author)
- Emory University
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- Inanc, Murat (author)
- Istanbul University
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Kalunian, Kenneth C. (author)
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- Jacobsen, Soren (author)
- Copenhagen University Hospital
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- Peschken, Christine A. (author)
- University of Manitoba
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- Kamen, Diane L. (author)
- Medical University of South Carolina
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- Askanase, Anca (author)
- Indian Institute of Technology
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- Theriault, Chris (author)
- Dalhousie University
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- Farewell, Vernon (author)
- University of Cambridge
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(creator_code:org_t)
- 2019-01-18
- 2019
- English.
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In: Arthritis and Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 71:2, s. 281-289
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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Abstract
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- Objective: To determine, in a large, multiethnic/multiracial, prospective inception cohort of patients with systemic lupus erythematosus (SLE), the frequency, attribution, clinical, and autoantibody associations with lupus psychosis and the short- and long-term outcomes as assessed by physicians and patients. Methods: Patients were evaluated annually for 19 neuropsychiatric (NP) events including psychosis. Scores on the Systemic Lupus Erythematosus Disease Activity Index 2000, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, and the Short Form 36 (SF-36) were recorded. Time to event and linear regressions were used as appropriate. Results: Of 1,826 SLE patients, 88.8% were female and 48.8% were Caucasian. The mean ± SD age was 35.1 ± 13.3 years, the mean ± SD disease duration was 5.6 ± 4.2 months, and the mean ± SD follow-up period was 7.4 ± 4.5 years. There were 31 psychotic events in 28 of 1,826 patients (1.53%), and most patients had a single event (26 of 28 [93%]). In the majority of patients (20 of 25 [80%]) and events (28 of 31 [90%]), psychosis was attributed to SLE, usually either in the year prior to or within 3 years of SLE diagnosis. Positive associations (hazard ratios [HRs] and 95% confidence intervals [95% CIs]) with lupus psychosis were previous SLE NP events (HR 3.59 [95% CI 1.16–11.14]), male sex (HR 3.0 [95% CI 1.20–7.50]), younger age at SLE diagnosis (per 10 years) (HR 1.45 [95% CI 1.01–2.07]), and African ancestry (HR 4.59 [95% CI 1.79–11.76]). By physician assessment, most psychotic events resolved by the second annual visit following onset, in parallel with an improvement in patient-reported SF-36 summary and subscale scores. Conclusion: Psychosis is an infrequent manifestation of NPSLE. Generally, it occurs early after SLE onset and has a significant negative impact on health status. As determined by patient and physician report, the short- and long-term outlooks are good for most patients, although careful follow-up is required.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Hanly, John G.
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Li, Qiuju
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Su, Li
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Urowitz, Murray ...
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Gordon, Caroline
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Bae, Sang Cheol
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show more...
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Romero-Diaz, Jua ...
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Sanchez-Guerrero ...
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Bernatsky, Sasha
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Clarke, Ann E.
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Wallace, Daniel ...
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Isenberg, David ...
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Rahman, Anisur
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Merrill, Joan T.
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Fortin, Paul R.
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Gladman, Dafna D ...
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Bruce, Ian N.
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Petri, Michelle
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Ginzler, Ellen M
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Dooley, M. A.
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Steinsson, Krist ...
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Ramsey-Goldman, ...
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Zoma, Asad A.
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Manzi, Susan
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Nived, Ola
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Jonsen, Andreas
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Khamashta, Munth ...
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Alarcón, Graciel ...
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van Vollenhoven, ...
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, ...
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Ramos-Casals, Ma ...
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Lim, S. Sam
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Inanc, Murat
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Kalunian, Kennet ...
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Jacobsen, Soren
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Peschken, Christ ...
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Kamen, Diane L.
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Askanase, Anca
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Theriault, Chris
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Farewell, Vernon
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Arthritis and Rh ...
- By the university
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Lund University
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Karolinska Institutet