Sökning: WFRF:(Litorell Jacob) >
A retrospective mul...
A retrospective multicenter cohort study of the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19
-
- Jonmarker, Sandra (författare)
- Karolinska Institutet,Karolinska Institute
-
- Litorell, Jacob (författare)
- Stockholm South General Hospital
-
- Alarcon, Felix (författare)
- Stockholm South General Hospital
-
visa fler...
-
- Al-Abani, Kais (författare)
- Karolinska University Hospital
-
- Björkman, Sofia (författare)
- Skåne University Hospital,Lund University
-
- Farm, Maria (författare)
- Karolinska Institutet,Karolinska Institute
-
- Grip, Jonathan (författare)
- Karolinska Institutet,Karolinska University Hospital
-
- Söderberg, Mårten (författare)
- Karolinska Institutet,Karolinska Institute
-
- Hollenberg, Jacob (författare)
- Karolinska Institutet,Karolinska Institute
-
- Wahlin, Rebecka Rubenson (författare)
- Karolinska Institutet,Karolinska Institute
-
- Kander, Thomas (författare)
- Lund University,Lunds universitet,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups,Skåne University Hospital
-
- Rimling, Liivi (författare)
- Stockholm South General Hospital
-
- Mårtensson, Johan (författare)
- Karolinska Institutet,Karolinska University Hospital
-
- Joelsson-Alm, Eva (författare)
- Karolinska Institutet,Karolinska Institute
-
- Dahlberg, Martin (författare)
- Karolinska Institutet,Karolinska Institute
-
- Cronhjort, Maria (författare)
- Karolinska Institutet,Karolinska Institute
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska.
-
Ingår i: Thrombosis Journal. - 1477-9560. ; 21, s. 1-11
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Patients with critical COVID-19 have a high risk of thromboembolism, but intensified thromboprophylaxis has not been proven beneficial. The activity of low-molecular-weight heparins can be monitored by measuring anti-Factor Xa. We aimed to study the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19.METHOD: This retrospective cohort study included adult patients with critical COVID-19 admitted to an intensive care unit at three Swedish hospitals between March 2020 and May 2021 with at least one valid peak and/or trough anti-Factor Xa value. Within the peak and trough categories, patients' minimum, median, and maximum values were determined. Logistic regressions with splines were used to assess associations.RESULTS: In total, 408 patients had at least one valid peak and/or trough anti-Factor Xa measurement, resulting in 153 patients with peak values and 300 patients with trough values. Lower peak values were associated with thromboembolism for patients' minimum (p = 0.01), median (p = 0.005) and maximum (p = 0.001) values. No association was seen between peak values and death or bleeding. Higher trough values were associated with death for median (p = 0.03) and maximum (p = 0.002) values and with both bleeding (p = 0.01) and major bleeding (p = 0.02) for maximum values, but there were no associations with thromboembolism.CONCLUSIONS: Measuring anti-Factor Xa activity may be relevant for administrating low-molecular-weight heparin to patients with critical COVID-19. Lower peak values were associated with an increased risk of thromboembolism, and higher trough values were associated with an increased risk of death and bleeding. Prospective studies are needed to confirm the results.TRIAL REGISTRATION: The study was retrospectively registered at Clinicaltrials.gov, NCT05256524, February 24, 2022.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Jonmarker, Sandr ...
-
Litorell, Jacob
-
Alarcon, Felix
-
Al-Abani, Kais
-
Björkman, Sofia
-
Farm, Maria
-
visa fler...
-
Grip, Jonathan
-
Söderberg, Mårte ...
-
Hollenberg, Jaco ...
-
Wahlin, Rebecka ...
-
Kander, Thomas
-
Rimling, Liivi
-
Mårtensson, Joha ...
-
Joelsson-Alm, Ev ...
-
Dahlberg, Martin
-
Cronhjort, Maria
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Thrombosis Journ ...
- Av lärosätet
-
Lunds universitet
-
Karolinska Institutet