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Why Is Amyloid-β PE...
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Reimand, JuhanAmsterdam UMC - Vrije Universiteit Amsterdam,Tallinn University of Technology
(författare)
Why Is Amyloid-β PET Requested After Performing CSF Biomarkers?
- Artikel/kapitelEngelska2020
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:7831eec0-78aa-4978-bdf8-93da45bb42df
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https://lup.lub.lu.se/record/7831eec0-78aa-4978-bdf8-93da45bb42dfURI
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https://doi.org/10.3233/JAD-190836DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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BACKGROUND: Amyloid-β positron emission tomography (PET) and cerebrospinal fluid (CSF) Aβ42 are considered interchangeable for clinical diagnosis of Alzheimer's disease. OBJECTIVE: To explore the clinical reasoning for requesting additional amyloid-β PET after performing CSF biomarkers. METHODS: We retrospectively identified 72 memory clinic patients who underwent amyloid-β PET after CSF biomarkers analysis for clinical diagnostic evaluation between 2011 and 2019. We performed patient chart reviews to identify factors which led to additional amyloid-β PET. Additionally, we assessed accordance with appropriate-use-criteria (AUC) for amyloid-β PET. RESULTS: Mean patient age was 62.0 (SD = 8.1) and mean Mini-Mental State Exam score was 23.6 (SD = 3.8). CSF analysis conflicting with the clinical diagnosis was the most frequent reason for requesting an amyloid-β PET scan (n = 53, 74%), followed by incongruent MRI (n = 16, 22%), unusual clinical presentation (n = 11, 15%) and young age (n = 8, 11%). An amyloid-β PET scan was rarely (n = 5, 7%) requested in patients with a CSF Aβ+/tau+ status. Fifteen (47%) patients with a post-PET diagnosis of AD had a predominantly non-amnestic presentation. In n = 11 (15%) cases, the reason that the clinician requested amyloid-β was not covered by AUC. This happened most often (n = 7) when previous CSF analysis did not support current clinical diagnosis, which led to requesting amyloid-β PET. CONCLUSION: In this single-center study, the main reason for requesting an amyloid-β PET scan after performing CSF biomarkers was the occurrence of a mismatch between the primary clinical diagnosis and CSF Aβ/tau results.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Groot, ColinVrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
(författare)
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Teunissen, Charlotte E.Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
(författare)
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Windhorst, Albert D.Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
(författare)
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Boellaard, RonaldVrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
(författare)
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Barkhof, FrederikUniversity College London,Amsterdam UMC - Vrije Universiteit Amsterdam
(författare)
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Nazarenko, SergeiTallinn University of Technology
(författare)
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van der Flier, Wiesje M.Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
(författare)
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van Berckel, Bart N.M.Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
(författare)
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Scheltens, PhilipAmsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
(författare)
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Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam(Swepub:lu)ri1513os
(författare)
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Bouwman, FemkeAmsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
(författare)
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Amsterdam UMC - Vrije Universiteit AmsterdamTallinn University of Technology
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Alzheimer's disease : JAD73:2, s. 559-5691387-2877
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Reimand, Juhan
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