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Sökning: WFRF:(Nazarenko Sergei) > (2020) > Why Is Amyloid-β PE...

  • Reimand, JuhanAmsterdam UMC - Vrije Universiteit Amsterdam,Tallinn University of Technology (författare)

Why Is Amyloid-β PET Requested After Performing CSF Biomarkers?

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020
  • 11 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:7831eec0-78aa-4978-bdf8-93da45bb42df
  • https://lup.lub.lu.se/record/7831eec0-78aa-4978-bdf8-93da45bb42dfURI
  • https://doi.org/10.3233/JAD-190836DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • BACKGROUND: Amyloid-β positron emission tomography (PET) and cerebrospinal fluid (CSF) Aβ42 are considered interchangeable for clinical diagnosis of Alzheimer's disease. OBJECTIVE: To explore the clinical reasoning for requesting additional amyloid-β PET after performing CSF biomarkers. METHODS: We retrospectively identified 72 memory clinic patients who underwent amyloid-β PET after CSF biomarkers analysis for clinical diagnostic evaluation between 2011 and 2019. We performed patient chart reviews to identify factors which led to additional amyloid-β PET. Additionally, we assessed accordance with appropriate-use-criteria (AUC) for amyloid-β PET. RESULTS: Mean patient age was 62.0 (SD = 8.1) and mean Mini-Mental State Exam score was 23.6 (SD = 3.8). CSF analysis conflicting with the clinical diagnosis was the most frequent reason for requesting an amyloid-β PET scan (n = 53, 74%), followed by incongruent MRI (n = 16, 22%), unusual clinical presentation (n = 11, 15%) and young age (n = 8, 11%). An amyloid-β PET scan was rarely (n = 5, 7%) requested in patients with a CSF Aβ+/tau+ status. Fifteen (47%) patients with a post-PET diagnosis of AD had a predominantly non-amnestic presentation. In n = 11 (15%) cases, the reason that the clinician requested amyloid-β was not covered by AUC. This happened most often (n = 7) when previous CSF analysis did not support current clinical diagnosis, which led to requesting amyloid-β PET. CONCLUSION: In this single-center study, the main reason for requesting an amyloid-β PET scan after performing CSF biomarkers was the occurrence of a mismatch between the primary clinical diagnosis and CSF Aβ/tau results.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Groot, ColinVrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam (författare)
  • Teunissen, Charlotte E.Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam (författare)
  • Windhorst, Albert D.Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam (författare)
  • Boellaard, RonaldVrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam (författare)
  • Barkhof, FrederikUniversity College London,Amsterdam UMC - Vrije Universiteit Amsterdam (författare)
  • Nazarenko, SergeiTallinn University of Technology (författare)
  • van der Flier, Wiesje M.Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam (författare)
  • van Berckel, Bart N.M.Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam (författare)
  • Scheltens, PhilipAmsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam (författare)
  • Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam(Swepub:lu)ri1513os (författare)
  • Bouwman, FemkeAmsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam (författare)
  • Amsterdam UMC - Vrije Universiteit AmsterdamTallinn University of Technology (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Alzheimer's disease : JAD73:2, s. 559-5691387-2877

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