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Adult-onset type 1 ...
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Ren, WenqianThird Affiliated Hospital of Sun Yat‐sen University
(författare)
Adult-onset type 1 diabetic patients with less severe clinical manifestation have less risk DR-DQ genotypes than childhood-onset patients
- Artikel/kapitelEngelska2021
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:f0c2b346-a12a-47f0-827f-2c468074e178
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https://lup.lub.lu.se/record/f0c2b346-a12a-47f0-827f-2c468074e178URI
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https://doi.org/10.1002/dmrr.3357DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Background: The aim of this study was to investigate differences in clinical features and HLA genotypes between adult-onset and childhood-onset patients with type 1 diabetes in a Chinese population. Materials and Methods: This study enrolled 716 Han Chinese patients with type 1 diabetes from Guangdong (258 childhood-onset and 458 adult-onset) to compare their clinical features. Of them 214 patients with classical type 1 diabetes (100 childhood-onset and 114 adult-onset) were selected for HLA DR and DQ genotyping by next-generation sequencing. Results: Adult-onset patients were characterized by longer duration of symptoms before diagnosis, lower frequency of DKA at disease onset, less frequent autoantibody positivity, higher serum C-peptide concentrations, and better glycemic control. These findings were replicated in the restricted cohort of 214 patients with classical type 1 diabetes. Compared with childhood-onset patients, adult-onset patients had a lower frequency of the DR9 haplotype, as well as lower frequency of high-risk DR3/DR4 and DR3/DR9 genotypes, but higher frequency of DR3/DR3 genotype and DR3/X, DR4/X or DR9/X (X, non-risk) genotypes. Conclusions: Adult-onset type 1 diabetic patients with susceptible haplotypes (DR3, DR4 or DR9) were more likely to carry protective DR-DQ haplotypes than childhood-onset patients, which suggested the association between less risk DR-DQ genotypes and the less severe clinical manifestation in adult-onset patients.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Yang, DaizhiThird Affiliated Hospital of Sun Yat‐sen University
(författare)
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Jiang, ZiyuThird Affiliated Hospital of Sun Yat‐sen University
(författare)
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Xian, YingxinThird Affiliated Hospital of Sun Yat‐sen University
(författare)
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Huang, QianwenThird Affiliated Hospital of Sun Yat‐sen University
(författare)
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Luo, SihuiUniversity of Science and Technology of China,Third Affiliated Hospital of Sun Yat‐sen University
(författare)
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Zheng, XueyingUniversity of Science and Technology of China
(författare)
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Yan, JinhuaThird Affiliated Hospital of Sun Yat‐sen University
(författare)
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Xu, WenThird Affiliated Hospital of Sun Yat‐sen University
(författare)
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Yao, BinThird Affiliated Hospital of Sun Yat‐sen University
(författare)
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Wang, Cong YiHuazhong University of Science and Technology
(författare)
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Bei, Jin XinSun Yat-sen University
(författare)
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Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,University of Science and Technology of China(Swepub:lu)endo-lgr
(författare)
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Noble, Janelle A.Children's Hospital Oakland Research Institute
(författare)
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Weng, JianpingThird Affiliated Hospital of Sun Yat‐sen University,University of Science and Technology of China
(författare)
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Third Affiliated Hospital of Sun Yat‐sen UniversityUniversity of Science and Technology of China
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes/Metabolism Research and Reviews: Wiley37:11520-75521520-7560
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Till lärosätets databas
- Av författaren/redakt...
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Ren, Wenqian
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Yang, Daizhi
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Jiang, Ziyu
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Xian, Yingxin
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Huang, Qianwen
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Luo, Sihui
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visa fler...
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Zheng, Xueying
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Yan, Jinhua
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Xu, Wen
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Yao, Bin
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Wang, Cong Yi
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Bei, Jin Xin
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Groop, Leif
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Noble, Janelle A ...
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Weng, Jianping
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes/Metabol ...
- Av lärosätet
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Lunds universitet