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Longitudinal change...
Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression
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- Majbour, Nour K. (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Hamad Bin Khalifa University
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- Vaikath, Nishant N. (författare)
- Lund University,Lunds universitet,Neural plasticitet och reparation,Forskargrupper vid Lunds universitet,Neural Plasticity and Repair,Lund University Research Groups,Hamad Bin Khalifa University
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- Eusebi, Paolo (författare)
- University of Perugia
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- Chiasserini, Davide (författare)
- University of Perugia
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- Ardah, Mustafa (författare)
- United Arab Emirates University
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- Varghese, Shiji (författare)
- United Arab Emirates University
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- Haque, M. Emdadul (författare)
- United Arab Emirates University
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- Tokuda, Takahiko (författare)
- Kyoto Prefectural University of Medicine
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- Auinger, Peggy (författare)
- University of Rochester
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- Calabresi, Paolo (författare)
- University of Perugia
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- Parnetti, Lucilla (författare)
- University of Perugia
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- El-Agnaf, Omar M A (författare)
- Hamad Bin Khalifa University
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(creator_code:org_t)
- 2016-10-06
- 2016
- Engelska 8 s.
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Ingår i: Movement Disorders. - : Wiley. - 0885-3185. ; 31:10, s. 1535-1542
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Parkinson's disease (PD) diagnosis is mainly based on clinical criteria, with a high risk of misdiagnosis. The identification of reliable biomarkers for disease diagnosis and progression has a key role for developing disease-modifying therapies. In this article, we investigated the longitudinal changes of CSF α-synuclein species in early PD patients and explored the potential use of these species as surrogate biomarkers for PD progression. Methods: We used our newly developed enzyme-linked immunosorbent assay systems for measuring different forms of α-synuclein, such as oligomeric-α-synuclein, phosphorylated-α-synuclein at serine 129, or total-α-synuclein in CSF from the longitudinal Deprenyl and Tocopherol Antioxidative Therapy for Parkinsonism study cohort (n = 121). CSF Alzheimer's disease biomarkers (total-tau, phosphorylated-tau, Aβ40, and Aβ42) were also measured for this cohort. Results: Interestingly, total-α-synuclein and oligomeric-α-synuclein levels significantly increased during the 2-year Deprenyl and Tocopherol Antioxidative Therapy for Parkinsonism study follow-up period, whereas phosphorylated-α-synuclein at serine 129 levels showed a longitudinal decrease. We have also noted an association between a change of the oligomeric-α-synuclein/total-α-synuclein ratio and a worsening of motor signs, in particular in the postural-instability and gait-difficulty dominant PD group. A strong positive correlation between the changes in CSF total-α-synuclein and oligomeric-α-synuclein during the 2-year Deprenyl and Tocopherol Antioxidative Therapy for Parkinsonism study was also noted (r = 0.84, P <.001). Conclusion: Our data show that CSF α-synuclein species have a dynamic pattern along the course of the disease, supporting their possible role as progression biomarkers for PD and their link with PD clinical phenotypes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- alpha-synuclein
- biomarkers
- DATATOP
- oligomers
- Parkinson's disease
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Majbour, Nour K.
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Vaikath, Nishant ...
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Eusebi, Paolo
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Chiasserini, Dav ...
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Ardah, Mustafa
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Varghese, Shiji
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visa fler...
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Haque, M. Emdadu ...
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Tokuda, Takahiko
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Auinger, Peggy
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Calabresi, Paolo
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Parnetti, Lucill ...
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El-Agnaf, Omar M ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Movement Disorde ...
- Av lärosätet
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Lunds universitet