Search: (WFRF:(Sjöbring Ulf)) mspu:(article) pers:(Ringdahl Ulrika)
> (2000-2004) >
Analysis of plasmin...
Analysis of plasminogen-binding M proteins of Streptococcus pyogenes.
-
- Sjöbring, Ulf (author)
- Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine
-
- Ringdahl, Ulrika (author)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH
-
(creator_code:org_t)
- 2000
- 2000
- English.
-
In: Methods. - 1095-9130. ; 21:2, s. 143-150
- Related links:
-
http://www.ncbi.nlm.... (free)
-
show more...
-
http://www.sciencedi...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Group A streptococci are common human pathogens that cause a variety of infections. They express M proteins which are important cell wall-bound type-specific virulence factors. We have found that a set of strains, associated primarily with skin infections, express M proteins that bind plasminogen and plasmin with high affinity. The binding is mediated by a 13-amino-acid internal repeated sequence located in the N-terminal surface-exposed portion of these M proteins. This sequence binds to kringle 2 in plasminogen, a domain that is not involved in the interaction with streptokinase, a potent group A streptococcal activator of plasminogen. It could be demonstrated that plasminogen, absorbed from plasma by growing group A streptococci expressing the plasminogen-binding M proteins, could be activated by exogenous and endogenous streptokinase, thereby providing the bacteria with a surface-associated enzyme that could act on the tissue barriers in the infected host.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
Methods
(Search for host publication in LIBRIS)
To the university's database