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Differential Effect...
Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus.
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- Ledri, Marco (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Sørensen, Andreas T (författare)
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- Grönning Madsen, Marita (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Christiansen, Søren H (författare)
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Ledri, Litsa Nikitidou (författare)
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- Cifra, Alessandra (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Experimental Epilepsy Group,Lund University Research Groups
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- Bengzon, Johan (författare)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Lindberg, Eva (författare)
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Pinborg, Lars H (författare)
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Jespersen, Bo (författare)
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Gøtzsche, Casper R (författare)
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Woldbye, David P D (författare)
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- Andersson, My (författare)
- Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurologi, Lund,Institutionen för kliniska vetenskaper, Lund,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Neurology, Lund,Department of Clinical Sciences, Lund,Experimental Epilepsy Group,Lund University Research Groups
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- Kokaia, Merab (författare)
- Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurologi, Lund,Institutionen för kliniska vetenskaper, Lund,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Neurology, Lund,Department of Clinical Sciences, Lund,Experimental Epilepsy Group,Lund University Research Groups
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(creator_code:org_t)
- 2015
- 2015
- Engelska.
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Ingår i: The Journal of Neuroscience. - 1529-2401. ; 35:26, s. 9622-9631
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https://portal.resea... (primary) (free)
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Development of novel disease-modifying treatment strategies for neurological disorders, which at present have no cure, represents a major challenge for today's neurology. Translation of findings from animal models to humans represents an unresolved gap in most of the preclinical studies. Gene therapy is an evolving innovative approach that may prove useful for clinical applications. In animal models of temporal lobe epilepsy (TLE), gene therapy treatments based on viral vectors encoding NPY or galanin have been shown to effectively suppress seizures. However, how this translates to human TLE remains unknown. A unique possibility to validate these animal studies is provided by a surgical therapeutic approach, whereby resected epileptic tissue from temporal lobes of pharmacoresistant patients are available for neurophysiological studies in vitro. To test whether NPY and galanin have antiepileptic actions in human epileptic tissue as well, we applied these neuropeptides directly to human hippocampal slices in vitro. NPY strongly decreased stimulation-induced EPSPs in dentate gyrus and CA1 (up to 30 and 55%, respectively) via Y2 receptors, while galanin had no significant effect. Receptor autoradiographic binding revealed the presence of both NPY and galanin receptors, while functional receptor binding was only detected for NPY, suggesting that galanin receptor signaling may be impaired. These results underline the importance of validating findings from animal studies in human brain tissue, and advocate for NPY as a more appropriate candidate than galanin for future gene therapy trials in pharmacoresistant TLE patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Ledri, Marco
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Sørensen, Andrea ...
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Grönning Madsen, ...
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Christiansen, Sø ...
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Ledri, Litsa Nik ...
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Cifra, Alessandr ...
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visa fler...
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Bengzon, Johan
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Lindberg, Eva
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Pinborg, Lars H
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Jespersen, Bo
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Gøtzsche, Casper ...
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Woldbye, David P ...
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Andersson, My
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Kokaia, Merab
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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Lunds universitet