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Hofbauer cells and coronavirus disease 2019 (COVID-19) in pregnancy : Molecular pathology analysis of villous macrophages, endothelial cells, and placental findings from 22 placentas infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without fetal transmission
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- Schwartz, David A (author)
- Medical College of Georgia
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- Baldewijns, Marcella (author)
- University Hospitals Leuven
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- Benachi, Alexandra (author)
- Antoine-Béclère Hospital
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- Bugatti, Mattia (author)
- University of Brescia
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- Bulfamante, Gaetano (author)
- CNR Institute for Photonics and Nanotechnologies (IFN-CNR)
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- Cheng, Ke (author)
- HistoWiz
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- Collins, Rebecca R J (author)
- University of Texas
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- Debelenko, Larisa (author)
- Columbia University
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- De Luca, Danièle (author)
- University of Paris-Saclay
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- Facchetti, Fabio (author)
- University of Brescia
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- Fitzgerald, Brendan (author)
- Cork University Hospital
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- Levitan, Daniel (author)
- SUNY Downstate Health Sciences University
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- Linn, Rebecca L (author)
- University of Pennsylvania
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- Marcelis, Lukas (author)
- University Hospitals Leuven
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- Morotti, Denise (author)
- Papa Giovanni XXIII Hospital
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- Morotti, Raffaella (author)
- Yale University
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- Patanè, Luisa (author)
- Papa Giovanni XXIII Hospital
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- Prevot, Sophie (author)
- Antoine-Béclère Hospital
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- Pulinx, Bianca (author)
- St. Trudo Hospital
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- Saad, Ali G (author)
- University of Miami
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- Schoenmakers, Sam (author)
- Erasmus University Medical Center
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- Strybol, David (author)
- St. Trudo Hospital
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- Thomas, Kristen (author)
- New York University
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- Tosi, Delfina (author)
- University of Milan
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- Toto, Valentina (author)
- ASST Santi Paolo e Carlo
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- van der Meeren, Lotte E (author)
- Leiden University Medical Centre
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- Verdijk, Robert M (author)
- Erasmus University Medical Center
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- Vivanti, Alexandre J (author)
- University of Paris-Saclay
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- Zaigham, Mehreen (author)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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(creator_code:org_t)
- 2021
- 2021
- English.
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In: Archives of pathology & laboratory medicine. - 0003-9985. ; 145:11, s. 1328-1340
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.5...
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Abstract
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- CONTEXT: - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can undergo maternal-fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental SARS-CoV-2 transmission is typically accompanied by chronic histiocytic intervillosaaitis together with necrosis and positivity of syncytiotrophoblast for SARSCoV-2. Hofbauer cells are placental macrophages that have been involved in viral diseases including HIV and Zika virus, but their involvement in SARS-CoV-2 in unknown.OBJECTIVE: - To determine whether SARS-CoV-2 can extend beyond the syncytiotrophoblast to enter Hofbauer cells, endothelium and other villous stromal cells in infected placentas of liveborn and stillborn infants.DESIGN: - Case-based retrospective analysis by 29 perinatal and molecular pathology specialists of placental findings from a preselected cohort of 22 SARS-CoV-2-infected placentas delivered to pregnant women testing positive for SARS-CoV-2 from 7 countries. Molecular pathology methods were used to investigate viral involvement of Hofbauer cells, villous capillary endothelium, syncytiotrophoblast and other fetal-derived cells.RESULTS: - Chronic histiocytic intervillositis and trophoblast necrosis was present in all 22 placentas (100%). SARS-CoV-2 was identified in Hofbauer cells from 4/22 placentas (18%). Villous capillary endothelial staining was positive in 2/22 cases (9%), both of which also had viral positivity in Hofbauer cells. Syncytiotrophoblast staining occurred in 21/22 placentas (95%). Hofbauer cell hyperplasia was present in 3/22 placentas (14%). In the 7 cases having documented transplacental infection of the fetus, 2 occurred in placentas with Hofbauer cell staining positive for SARS-CoV-2.CONCLUSIONS: - SARS-CoV-2 can extend beyond the trophoblast into the villous stroma, involving Hofbauer cells and capillary endothelial cells, in a small number of infected placentas. Most cases of SARS-CoV-2 transplacental fetal infection occur without Hofbauer cell involvement.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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- ref (subject category)
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Schwartz, David ...
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Baldewijns, Marc ...
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Benachi, Alexand ...
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Bugatti, Mattia
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Bulfamante, Gaet ...
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Cheng, Ke
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Collins, Rebecca ...
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Debelenko, Laris ...
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De Luca, Danièle
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Facchetti, Fabio
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Fitzgerald, Bren ...
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Levitan, Daniel
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Linn, Rebecca L
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Marcelis, Lukas
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Morotti, Denise
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Morotti, Raffael ...
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Patanè, Luisa
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Prevot, Sophie
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Pulinx, Bianca
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Saad, Ali G
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Schoenmakers, Sa ...
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Strybol, David
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Thomas, Kristen
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Tosi, Delfina
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Toto, Valentina
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van der Meeren, ...
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Verdijk, Robert ...
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Vivanti, Alexand ...
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Zaigham, Mehreen
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