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The protective gene...
The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals
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- Salvadó, Gemma (författare)
- Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute
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- Ferreira, Daniel (författare)
- Karolinska Institutet,Karolinska Institute,Mayo Clinic Minnesota
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- Operto, Grégory (författare)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES),Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute
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visa fler...
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- Cumplido-Mayoral, Irene (författare)
- Pasqual Maragall Foundation for Research on Alzheimer,Pompeu Fabra University
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- Arenaza-Urquijo, Eider M. (författare)
- Pasqual Maragall Foundation for Research on Alzheimer,Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES),Hospital del Mar Medical Research Institute
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- Cacciaglia, Raffaele (författare)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES),Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute
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- Falcon, Carles (författare)
- CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute
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- Vilor-Tejedor, Natàlia (författare)
- Erasmus University Medical Center,Barcelona Institute of Science and Technology,Pasqual Maragall Foundation for Research on Alzheimer,Pompeu Fabra University
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- Minguillon, Carolina (författare)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES),Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute
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- Groot, Colin (författare)
- Vrije Universiteit Amsterdam
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- van der Flier, Wiesje M. (författare)
- Vrije Universiteit Amsterdam
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- Barkhof, Frederik (författare)
- University College London,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Scheltens, Philip (författare)
- Vrije Universiteit Amsterdam
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- Ossenkoppele, Rik (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam
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- Kern, Silke (författare)
- Sahlgrenska Academy
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- Zettergren, Anna (författare)
- Sahlgrenska Academy
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- Skoog, Ingmar (författare)
- Sahlgrenska Academy
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- Hort, Jakub (författare)
- St. Anne's University Hospital Brno,University Hospital Motol
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- Stomrud, Erik (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- van Westen, Danielle (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Skåne University Hospital
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- Hansson, Oskar (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Molinuevo, José Luis (författare)
- H. Lundbeck A/S,Pasqual Maragall Foundation for Research on Alzheimer
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- Wahlund, Lars Olof (författare)
- Karolinska Institutet,Karolinska Institute
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- Westman, Eric (författare)
- Karolinska Institutet,Karolinska Institute,King's College London
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- Gispert, Juan Domingo (författare)
- Hospital del Mar Medical Research Institute,Pompeu Fabra University,Pasqual Maragall Foundation for Research on Alzheimer,CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)
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(creator_code:org_t)
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- 2021-12-08
- 2022
- Engelska.
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Ingår i: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 18:7, s. 1383-1395
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: Harboring two copies of the apolipoprotein E (APOE) ε2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired individuals has not yet been described. Methods: Multicenter brain magnetic resonance images (MRIs) from cognitively unimpaired ε2 homozygotes were matched (1:1) against all other APOE genotypes for relevant confounders (n = 223). GM volumes of ε2 genotypic groups were compared to each other and to the reference group (APOE ε3/ε3). Results: Carrying at least one ε2 allele was associated with larger GM volumes in brain areas typically affected by AD and also in areas associated with cognitive resilience. APOE ε2 homozygotes, but not APOE ε2 heterozygotes, showed larger GM volumes in areas related to successful aging. Discussion: In addition to the known resistance against amyloid-β deposition, the larger GM volumes in key brain regions may confer APOE ε2 homozygotes additional protection against AD-related cognitive decline.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease
- Alzheimer's disease signature
- apolipoprotein E ε2 carrier
- brain maintenance
- brain morphology
- brain reserve
- cognitive reserve
- magnetic resonance
- multi-site
- resilience signature
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Salvadó, Gemma
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Ferreira, Daniel
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Operto, Grégory
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Cumplido-Mayoral ...
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Arenaza-Urquijo, ...
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Cacciaglia, Raff ...
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visa fler...
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Falcon, Carles
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Vilor-Tejedor, N ...
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Minguillon, Caro ...
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Groot, Colin
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van der Flier, W ...
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Barkhof, Frederi ...
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Scheltens, Phili ...
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Ossenkoppele, Ri ...
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Kern, Silke
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Zettergren, Anna
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Skoog, Ingmar
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Hort, Jakub
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Stomrud, Erik
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van Westen, Dani ...
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Hansson, Oskar
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Molinuevo, José ...
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Wahlund, Lars Ol ...
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Westman, Eric
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Gispert, Juan Do ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Alzheimer's and ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet