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  • Kenborg, LineDanish Cancer Society (author)

Neurologic disorders in 4858 survivors of central nervous system tumors in childhood-an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2018-05-30
  • Oxford University Press (OUP),2019
  • 12 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:79c13ac7-8b70-4e99-aa28-fd28cccd1eb4
  • https://lup.lub.lu.se/record/79c13ac7-8b70-4e99-aa28-fd28cccd1eb4URI
  • https://doi.org/10.1093/neuonc/noy094DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: A comprehensive overview of neurologic complications among survivors of central nervous system (CNS) tumors in childhood is lacking. We aimed to investigate the risk for these disorders in a large, population-based study with outcome measures from nationwide hospital registries. Methods: We identified 4858 five-year survivors with diagnoses of CNS tumor in childhood in Denmark, Iceland, Finland, and Sweden in 1943-2007, and 166658 matched population comparison subjects. Inpatient discharge diagnoses of neurologic disorders were used to calculate relative risks (RRs) and absolute excess risks (AERs). Results: A neurologic disorder was verified in 1309 survivors, while 92.4 were expected, yielding an overall RR of 14.2 (95% confidence interval [CI]: 13.3-15.1) and an AER of 20 hospitalizations per 1000 persons per year. The risks remained increased more than 20 years after diagnosis (RR: 6.3, 95% CI: 5.6-7.2; AER: 11, 9-12). The most frequent diagnoses were epilepsy (affecting 14.1% of all survivors) followed by hydrocephalus (9.5%) and paralytic syndromes (4.2%), with RRs of 28.7 (95% CI: 26.0-31.6), 243 (95% CI: 190-311), and 40.3 (95% CI: 33.1-49.2), respectively. Of these outcomes, 30%-40% were diagnosed prior to or synchronously with the CNS tumor. The survivors had highly increased RRs for infectious diseases of the CNS, disorders of cranial nerves, and degenerative diseases of the nervous system. Conclusions: Survivors of childhood CNS tumors are at markedly increased risk for neurologic disorders throughout their lives. Health care professionals must be aware of survivors who might benefit from preventive interventions and intensive follow-up.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Winther, Jeanette FalckDanish Cancer Society (author)
  • Linnet, Karen MarkussenAarhus University Hospital (author)
  • Krøyer, AnjaDanish Cancer Society (author)
  • Albieri, VannaDanish Cancer Society (author)
  • Holmqvist, Anna SällforsLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-as- (author)
  • Tryggvadottir, LaufeyUniversity of Iceland,Icelandic Cancer Registry (author)
  • Madanat-Harjuoja, Laura MariaFinnish Cancer Registry (author)
  • Stovall, MarilynUniversity of Texas (author)
  • Hasle, HenrikAarhus University Hospital (author)
  • Olsen, Jørgen H.Danish Cancer Society (author)
  • Danish Cancer SocietyAarhus University Hospital (creator_code:org_t)
  • ALiCCS study group

Related titles

  • In:Neuro-Oncology: Oxford University Press (OUP)21:1, s. 125-1361523-58661522-8517

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