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Variant ABO Blood G...
Variant ABO Blood Group Alleles, Secretor Status, and Risk of Pancreatic Cancer: Results from the Pancreatic Cancer Cohort Consortium
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Wolpin, Brian M. (author)
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Kraft, Peter (author)
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Xu, Mousheng (author)
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Steplowski, Emily (author)
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- Olsson, Martin L (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Transfusionsmedicin,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Transfusion Medicine,Lund University Research Groups
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Arslan, Alan A. (author)
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Bueno-de-Mesquita, H. Bas (author)
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Gross, Myron (author)
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Helzlsouer, Kathy (author)
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Jacobs, Eric J. (author)
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LaCroix, Andrea (author)
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Petersen, Gloria (author)
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Stolzenberg-Solomon, Rachael Z. (author)
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Zheng, Wei (author)
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Albanes, Demetrius (author)
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Allen, Naomi E. (author)
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Amundadottir, Laufey (author)
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Austin, Melissa A. (author)
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Boutron-Ruault, Marie-Christine (author)
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Buring, Julie E. (author)
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Canzian, Federico (author)
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Chanock, Stephen J. (author)
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Gaziano, J. Michael (author)
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Giovannucci, Edward L. (author)
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Näringsforskning
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Hankinson, Susan E. (author)
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Hoover, Robert N. (author)
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Hunter, David J. (author)
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Hutchinson, Amy (author)
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Jacobs, Kevin B. (author)
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Kooperberg, Charles (author)
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Mendelsohn, Julie B. (author)
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Michaud, Dominique S. (author)
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Overvad, Kim (author)
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Patel, Alpa V. (author)
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Sanchez, Maria-Jose (author)
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Sansbury, Leah (author)
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Shu, Xiao-Ou (author)
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Slimani, Nadia (author)
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Tobias, Geoffrey S. (author)
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Trichopoulos, Dimitrios (author)
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Vineis, Paolo (author)
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Visvanathan, Kala (author)
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Virtamo, Jarmo (author)
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Wactawski-Wende, Jean (author)
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Watters, Joanne (author)
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Yu, Kai (author)
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Zeleniuch-Jacquotte, Anne (author)
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Hartge, Patricia (author)
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Fuchs, Charles S. (author)
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Cancer Epidemiology Biomarkers & Prevention. - 1538-7755 .- 1055-9965. ; 19:12, s. 3140-3149
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Background: Subjects with non-O ABO blood group alleles have increased risk of pancreatic cancer. Glycosyltransferase activity is greater for the A(1) versus A(2) variant, whereas O01 and O02 variants are nonfunctioning. We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotype would modify the association with risk. Methods: We determined ABO variants and secretor phenotype from single nucleotide polymorphisms in ABO and FUT2 genes in 1,533 cases and 1,582 controls from 12 prospective cohort studies. Adjusted odds ratios (OR) for pancreatic cancer were calculated using logistic regression. Results: An increased risk was observed in participants with A(1) but not A(2) alleles. Compared with subjects with genotype O/O, genotypes A(2)/O, A(2)/A(1), A(1)/O, and A(1)/A(1) had ORs of 0.96 (95% CI, 0.72-1.26), 1.46 (95% CI, 0.98-2.17), 1.48 (95% CI, 1.23-1.78), and 1.71 (95% CI, 1.18-2.47). Risk was similar for O01 and O02 variant O alleles. Compared with O01/O01, the ORs for each additional allele of O02, A(1), and A(2) were 1.00 (95% CI, 0.87-1.14), 1.38 (95% CI, 1.20-1.58), and 0.96 (95% CI, 0.77-1.20); P-value, O01 versus O02 = 0.94, A(1) versus A(2) = 0.004. Secretor phenotype was not an effect modifier (P-interaction = 0.63). Conclusions: Among participants in a large prospective cohort consortium, ABO allele subtypes corresponding to increased glycosyltransferase activity were associated with increased pancreatic cancer risk. Impact: These data support the hypothesis that ABO glycosyltransferase activity influences pancreatic cancer risk rather than actions of other nearby genes on chromosome 9q34. Cancer Epidemiol Biomarkers Prev; 19(12); 3140-9. (C) 2010 AACR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
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- By the author/editor
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Wolpin, Brian M.
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Kraft, Peter
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Xu, Mousheng
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Steplowski, Emil ...
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Olsson, Martin L
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Arslan, Alan A.
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show more...
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Bueno-de-Mesquit ...
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Gross, Myron
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Helzlsouer, Kath ...
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Jacobs, Eric J.
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LaCroix, Andrea
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Petersen, Gloria
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Stolzenberg-Solo ...
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Zheng, Wei
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Albanes, Demetri ...
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Allen, Naomi E.
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Amundadottir, La ...
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Austin, Melissa ...
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Boutron-Ruault, ...
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Buring, Julie E.
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Canzian, Federic ...
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Chanock, Stephen ...
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Gaziano, J. Mich ...
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Giovannucci, Edw ...
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Hallmans, Göran, ...
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Hankinson, Susan ...
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Hoover, Robert N ...
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Hunter, David J.
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Hutchinson, Amy
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Jacobs, Kevin B.
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Kooperberg, Char ...
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Mendelsohn, Juli ...
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Michaud, Dominiq ...
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Overvad, Kim
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Patel, Alpa V.
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Sanchez, Maria-J ...
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Sansbury, Leah
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Shu, Xiao-Ou
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Slimani, Nadia
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Tobias, Geoffrey ...
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Trichopoulos, Di ...
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Vineis, Paolo
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Visvanathan, Kal ...
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Virtamo, Jarmo
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Wactawski-Wende, ...
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Watters, Joanne
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Yu, Kai
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Zeleniuch-Jacquo ...
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Hartge, Patricia
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Fuchs, Charles S ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Lund University
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Umeå University