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Sökning: WFRF:(Ehinger Johannes K) > Evaluation of Diffu...

  • Karlsson, MichaelLund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups,Cochin Hospital,Copenhagen University Hospital (författare)

Evaluation of Diffusion Tensor Imaging and Fluid Based Biomarkers in a Large Animal Trial of Cyclosporine in Focal Traumatic Brain Injury

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Mary Ann Liebert Inc,2021
  • 9 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:79ef5c8a-b0e1-4d71-ba6d-27cc3e00a042
  • https://lup.lub.lu.se/record/79ef5c8a-b0e1-4d71-ba6d-27cc3e00a042URI
  • https://doi.org/10.1089/neu.2020.7317DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • All phase III trials evaluating medical treatments for traumatic brain injury (TBI), performed to date, have failed. To facilitate future success there is a need for novel outcome metrics that can bridge pre-clinical studies to clinical proof of concept trials. Our objective was to assess diffusion tensor imaging (DTI) and biofluid-based biomarkers as efficacy outcome metrics in a large animal study evaluating the efficacy of cyclosporine in TBI. This work builds on our previously published study that demonstrated a reduced volume of injury by 35% with cyclosporine treatment based on magnetic resonance imaging (MRI) results. A focal contusion injury was induced in piglets using a controlled cortical impact (CCI) device. Cyclosporine in a novel Cremophor/Kolliphor EL-free lipid emulsion, NeuroSTAT, was administered by continuous intravenous infusion for 5 days. The animals underwent DTI on day 5. Glial fibrillary acidic protein (GFAP), as a measure of astroglia injury, and neurofilament light (NF-L), as a measure of axonal injury, were measured in blood on days 1, 2, and 5, and in cerebrospinal fluid (CSF) on day 5 post-injury. Normalized fractional anisotropy (FA) was significantly (p = 0.027) higher in in the treatment group, indicating preserved tissue integrity with treatment. For the biomarkers, we observed a statistical trend of a decreased level of NF-L in CSF (p = 0.051), in the treatment group relative to placebo, indicating less axonal injury. Our findings suggest that DTI, and possibly CSF NF-L, may be feasible as translational end-points assessing neuroprotective drugs in TBI.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Yang, ZhihuiFlorida Museum Natural History (författare)
  • Chawla, SanjeevCochin Hospital (författare)
  • Delso, NileCochin Hospital (författare)
  • Pukenas, BryanCochin Hospital (författare)
  • Elmér, EskilLund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups,Abliva AB(Swepub:lu)expb-eel (författare)
  • Hugerth, MatildaAbliva AB (författare)
  • Margulies, Susan S.Georgia Institute of Technology (författare)
  • Ehinger, JohannesLund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups(Swepub:lu)med-jeg (författare)
  • Hansson, Magnus J.Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups,Abliva AB(Swepub:lu)expb-mha (författare)
  • Wang, Kevin K.W.Florida Museum Natural History (författare)
  • Kilbaugh, Todd J.Cochin Hospital (författare)
  • Mitokondriell MedicinForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Neurotrauma: Mary Ann Liebert Inc38:13, s. 1870-18780897-71511557-9042

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