SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Polyak Kornelia)
 

Search: WFRF:(Polyak Kornelia) > (2016) > Direct Transcriptio...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Shlien, AdamWellcome Trust Sanger Institute (author)

Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • Elsevier BV,2016
  • 15 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:79f2cada-6cc2-4680-85c7-d0f995e56dc1
  • https://lup.lub.lu.se/record/79f2cada-6cc2-4680-85c7-d0f995e56dc1URI
  • https://doi.org/10.1016/j.celrep.2016.07.028DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise. To catalog the rules governing how somatic mutation exerts direct transcriptional effects, we developed an exhaustive pipeline for analyzing RNA sequencing data, which we integrated with whole genomes from 23 breast cancers. Using X-inactivation analyses, we found that cancer cells are more transcriptionally active than intermixed stromal cells. This is especially true in estrogen receptor (ER)-negative tumors. Overall, 59% of substitutions were expressed. Nonsense mutations showed lower expression levels than expected, with patterns characteristic of nonsense-mediated decay. 14% of 4,234 rearrangements caused transcriptional abnormalities, including exon skips, exon reusage, fusions, and premature polyadenylation. We found productive, stable transcription from sense-to-antisense gene fusions and gene-to-intergenic rearrangements, suggesting that these mutation classes drive more transcriptional disruption than previously suspected. Systematic integration of transcriptome with genome data reveals the rules by which transcriptional machinery interprets somatic mutation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Raine, KeiranWellcome Trust Sanger Institute (author)
  • Fuligni, FabioHospital for Sick Children, Toronto (author)
  • Arnold, RolandHospital for Sick Children, Toronto (author)
  • Nik-Zainal, SerenaWellcome Trust Sanger Institute (author)
  • Dronov, SergeWellcome Trust Sanger Institute (author)
  • Mamanova, LiraWellcome Trust Sanger Institute (author)
  • Rosic, AndrejHospital for Sick Children, Toronto (author)
  • Ju, Young SeokWellcome Trust Sanger Institute (author)
  • Cooke, Susanna L.Wellcome Trust Sanger Institute (author)
  • Ramakrishna, ManasaWellcome Trust Sanger Institute (author)
  • Papaemmanuil, ElliWellcome Trust Sanger Institute (author)
  • Davies, Helen R.Wellcome Trust Sanger Institute (author)
  • Tarpey, Patrick S.Wellcome Trust Sanger Institute (author)
  • Van Loo, PeterCatholic University of Leuven,Wellcome Trust Sanger Institute (author)
  • Wedge, David C.Wellcome Trust Sanger Institute (author)
  • Jones, David R.Wellcome Trust Sanger Institute (author)
  • Martin, SanchaWellcome Trust Sanger Institute (author)
  • Marshall, JohnWellcome Trust Sanger Institute (author)
  • Anderson, ElizabethWellcome Trust Sanger Institute (author)
  • Hardy, ClaireWellcome Trust Sanger Institute (author)
  • Barbashina, ViolettaInstitute of Cancer Research London (author)
  • Aparicio, Samuel A J RBritish Columbia Cancer Agency (author)
  • Sauer, TorillOslo university hospital (author)
  • Garred, ØysteinOslo university hospital (author)
  • Vincent-Salomon, AnneCurie Institute, Paris (author)
  • Mariani, OdetteCurie Institute, Paris (author)
  • Boyault, SandrineCentre Léon Bérard (author)
  • Fatima, AquilaDana-Farber Cancer Institute (author)
  • Langerød, AnitaUniversity of Oslo (author)
  • Borg, ÅkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-abo (author)
  • Thomas, GillesCentre Léon Bérard (author)
  • Richardson, Andrea L.Dana-Farber Cancer Institute (author)
  • Børresen-Dale, Anne LiseUniversity of Oslo,Oslo university hospital (author)
  • Polyak, KorneliaDana-Farber Cancer Institute (author)
  • Stratton, Michael R.Wellcome Trust Sanger Institute (author)
  • Campbell, Peter J.Addenbrooke's Hospital,University of Cambridge,Wellcome Trust Sanger Institute (author)
  • Wellcome Trust Sanger InstituteHospital for Sick Children, Toronto (creator_code:org_t)

Related titles

  • In:Cell Reports: Elsevier BV16:7, s. 2032-20462211-1247

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view