Estimating the parameters of the operational model of pharmacological agonism

Frigyesi, AttilaLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine (författare)

The aim of this work is practical. We show that the parameters of the widely used operational model of pharmacological agonism are difficult to estimate from single dose-response curves. The parameters can be estimated using pairs of dose-response curves (usually treatment and control) sharing some parameters. Confidence bands for the estimators are developed. In the case of multiple dose-response curve pairs one can employ a non-linear mixed effects model to allow for inter-individual variation. The point estimates and the confidence intervals thus obtained are similar to the more naive construction based on mean and standard errors of parameter estimates. To test for difference of certain parameters between treatment and control we employ a permutation test and Wald's test. Copyright (c) 2005 John Wiley & Sons, Ltd.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
confidence interval
of pharmacological agonism
operational model
dose-response curves
concentration-response curves
mixed effects

Hössjer, OlaLund University,Lunds universitet,Matematisk statistik,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Mathematical Statistics,Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)mats-oho (författare)
KardiologiSektion II (creator_code:org_t)

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