Sökning: id:"swepub:oai:lup.lub.lu.se:7b2b5422-14a1-433e-b133-713a1dbd3aac" >
Complete Clinical R...
-
Kleef, RalfDr. Kleef hyperthermie
(författare)
Complete Clinical Remission of Stage IV Triple-Negative Breast Cancer Lung Metastasis Administering Low-Dose Immune Checkpoint Blockade in Combination With Hyperthermia and Interleukin-2
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
-
2018-09-07
-
SAGE Publications,2018
-
7 s.
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:7b2b5422-14a1-433e-b133-713a1dbd3aac
-
https://lup.lub.lu.se/record/7b2b5422-14a1-433e-b133-713a1dbd3aacURI
-
https://doi.org/10.1177/1534735418794867DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
The prognosis of triple-negative breast cancer with metastases after chemotherapy remains dismal. We report the case of a 50-year-old female with first disease recurrence at the axillary lymph node and, later on, bilateral pulmonary metastases with severe shortness of breath. The patient received low-dose immune checkpoint blockade (concurrent nivolumab and ipilimumab) weekly over 3 weeks with regional hyperthermia 3 times a week, followed by systemic fever-range hyperthermia induced by interleukin-2 for 5 days. She went into complete remission of her pulmonary metastases with transient WHO I-II diarrhea and skin rash. The patient remained alive for 27 months after the start of treatment, with recurrence of metastases as a sternal mass, and up to 3 cm pleural metastases. This exceptional response should instigate further research efforts with this protocol, which consists only of approved drugs and treatments.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Moss, RalphCancer Decisions, Lermont
(författare)
-
Szasz, A. MarcellLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Semmelweis University(Swepub:lu)ma4462sz
(författare)
-
Bohdjalian, ArthurRudolfinerhaus, Vienna
(författare)
-
Bojar, HansNextGen Oncology Group, Düsseldorf
(författare)
-
Bakacs, TiborPRET Therapeutics Ltd, Budapest
(författare)
-
Dr. Kleef hyperthermieCancer Decisions, Lermont
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Integrative Cancer Therapies: SAGE Publications17:4, s. 1297-13031534-73541552-695X
Internetlänk
Hitta via bibliotek
Till lärosätets databas