Sökning: WFRF:(Ivarsson Sten)
> (2020-2023) >
Evaluation of the R...
-
Törn, CarinaLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Wallenberglaboratoriet, Malmö,Celiac Disease and Diabetes Unit,Lund University Research Groups,Faculty of Medicine,The Wallenberg Laboratory, Malmö
(författare)
Evaluation of the RSR 3 screen ICA™ and 2 screen ICA™ as screening assays for type 1 diabetes in Sweden
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
-
2022-02-26
-
Springer Science and Business Media LLC,2022
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:7b464c83-ca32-442b-b166-994ad1fca645
-
https://lup.lub.lu.se/record/7b464c83-ca32-442b-b166-994ad1fca645URI
-
https://doi.org/10.1007/s00592-022-01856-5DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
Aim: The study aim was to evaluate the RSR 3 Screen ICA™ and 2 Screen ICA™ for detection of islet cell autoimmunity in healthy Swedish subjects and patients with newly diagnosed type 1 diabetes (T1D). Methods: 3 Screen is designed for combined detection of autoantibodies to glutamic acid decarboxylase (GADA), to the islet antigen IA-2 (IA-2A) and to zinc transporter 8 (ZnT8A), while 2 Screen detects GADA and IA-2A. Serum samples from 100 T1D patients at onset and 200 healthy controls were studied. Results: 3 Screen achieved 93% assay sensitivity and 97.5% specificity, while 2 Screen achieved 91% assay sensitivity and 98.5% specificity. Samples were also tested in assays for individual autoantibodies. There was only one 3 Screen positive healthy control sample (0.5%) that was positive for multiple autoantibodies (IA-2A and ZnT8A). In contrast, most of the 93 3 Screen positive patients were positive for multiple autoantibodies with 72% (67/93) positive for both GADA and IA-2A and 57% (53/93) positive for three autoantibodies (GADA, IA-2A and ZnT8A). Insulin autoantibodies (IAA, measured by radioimmunoassay) were positive in 13 patients and two healthy controls. Conclusion: 3 Screen achieved high sensitivity and specificity, suitable for islet cell autoimmunity screening in a healthy population. In the case of 3 Screen positivity, further assays for GADA, IA-2A and ZnT8A are required to check for multiple autoantibody positivity, a hallmark for progression to T1D. In addition, testing for IAA in children below two years of age is warranted.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Vaziri-Sani, FaribaLund University,Lunds universitet,LU Samverkan,Sektionen Forskning, samverkan och innovation,Universitetsförvaltningen,Universitetets ledning och förvaltning,Systemvirologi,Forskargrupper vid Lunds universitet,Cooperation office,Research, Collaboration and Innovation,Central Administration,University Management and Central Administration,Systems Virology,Lund University Research Groups(Swepub:lu)fa3255va
(författare)
-
Ramelius, AnitaLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Celiac Disease and Diabetes Unit,Lund University Research Groups,Faculty of Medicine(Swepub:lu)endo-ani
(författare)
-
Elding Larsson, HelenaLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Paediatric Endocrinology,Lund University Research Groups,Faculty of Medicine(Swepub:lu)pedi-hla
(författare)
-
Ivarsson, Sten AndersLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Pediatrisk endokrinologi,Lund University Bioimaging Center,Medicinska fakulteten,Celiac Disease and Diabetes Unit,Lund University Research Groups,Paediatric Endocrinology,Faculty of Medicine(Swepub:lu)pedi-siv
(författare)
-
Amoroso, MarieRSR Limited
(författare)
-
Furmaniak, JadwigaRSR Limited
(författare)
-
Powell, MichaelRSR Limited
(författare)
-
Smith, Bernard ReesRSR Limited
(författare)
-
Celiaki och diabetesForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Acta Diabetologica: Springer Science and Business Media LLC59:6, s. 773-7810940-54291432-5233
Internetlänk
Hitta via bibliotek
Till lärosätets databas