Search: (WFRF:(Bruce Ian N.)) lar1:(lu) pers:(Isenberg David A.) pers:(Dooley M A) >
Prediction of Hospi...
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Legge, AlexandraDalhousie University
(author)
Prediction of Hospitalizations in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-02-17
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Wiley,2022
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10 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:7b701deb-ebfa-4d05-8e22-f945bf3d5993
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https://lup.lub.lu.se/record/7b701deb-ebfa-4d05-8e22-f945bf3d5993URI
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https://doi.org/10.1002/acr.24504DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148858603URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Objective: The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) predicts mortality and damage accrual in systemic lupus erythematosus (SLE), but its association with hospitalizations has not been described. Our objective was to estimate the association of baseline SLICC-FI values with future hospitalizations in the SLICC inception cohort. Methods: Baseline SLICC-FI scores were calculated. The number and duration of inpatient hospitalizations during follow-up were recorded. Negative binomial regression was used to estimate the association between baseline SLICC-FI values and the rate of hospitalizations per patient-year of follow-up. Linear regression was used to estimate the association of baseline SLICC-FI scores with the proportion of follow-up time spent in the hospital. Multivariable models were adjusted for relevant baseline characteristics. Results: The 1,549 patients with SLE eligible for this analysis were mostly female (88.7%), with a mean ± SD age of 35.7 ± 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9–1.5) at baseline. Mean ± SD baseline SLICC-FI was 0.17 ± 0.08. During mean ± SD follow-up of 7.2 ± 3.7 years, 614 patients (39.6%) experienced 1,570 hospitalizations. Higher baseline SLICC-FI values (per 0.05 increment) were associated with more frequent hospitalizations during follow-up, with an incidence rate ratio of 1.21 (95% confidence interval [95% CI] 1.13–1.30) after adjustment for baseline age, sex, glucocorticoid use, immunosuppressive use, ethnicity/location, SLE Disease Activity Index 2000 score, SLICC/American College of Rheumatology Damage Index score, and disease duration. Among patients with ≥1 hospitalization, higher baseline SLICC-FI values predicted a greater proportion of follow-up time spent hospitalized (relative rate 1.09 [95% CI 1.02–1.16]). Conclusion: The SLICC-FI predicts future hospitalizations among incident SLE patients, further supporting the SLICC-FI as a valid health measure in SLE.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kirkland, SusanDalhousie University
(author)
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Rockwood, KennethDalhousie University
(author)
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Andreou, PantelisDalhousie University
(author)
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Bae, Sang CheolHanyang University Hospital for Rheumatic Disease
(author)
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Gordon, CarolineUniversity of Birmingham
(author)
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Romero-Diaz, JuanitaSalvador Zubirán National Institute of Health Sciences and Nutrition
(author)
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Sanchez-Guerrero, JorgeSalvador Zubirán National Institute of Health Sciences and Nutrition
(author)
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Wallace, Daniel J.University of California, Los Angeles
(author)
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Bernatsky, SashaMcGill University
(author)
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Clarke, Ann E.Cumming School of Medicine
(author)
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Merrill, Joan T.Oklahoma Medical Research Foundation
(author)
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Ginzler, Ellen M.SUNY Downstate Health Sciences University,Feinstein Institute for Medical Research
(author)
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Fortin, Paul R.Centre hospitalier universitaire de Québec
(author)
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Gladman, Dafna D.University of Toronto
(author)
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Urowitz, Murray B.University of Toronto
(author)
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Bruce, Ian N.University of Manchester
(author)
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Isenberg, David A.University College London,Indian Institute of Technology
(author)
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Rahman, AnisurUniversity College London
(author)
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Alarcón, Graciela S.University of Alabama
(author)
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Petri, MichelleJohns Hopkins University School of Medicine
(author)
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Khamashta, Munther A.St Thomas' Hospital
(author)
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Dooley, M. A.University of North Carolina
(author)
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Ramsey-Goldman, RosalindNorthwestern University Feinberg School of Medicine
(author)
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Manzi, SusanAllegheny Health Network
(author)
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Zoma, Asad A.Hairmyres Hospital
(author)
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Aranow, CynthiaFeinstein Institute for Medical Research
(author)
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Mackay, MegganFeinstein Institute for Medical Research
(author)
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Ruiz-Irastorza, GuillermoBiocruces Bizkaia Health Research Institute
(author)
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Lim, S. SamEmory University
(author)
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Inanc, Murat
(author)
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van Vollenhoven, Ronald F.Karolinska Institute
(author)
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Jonsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups(Swepub:lu)reum-ajo
(author)
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Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-oni
(author)
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Ramos-Casals, ManuelHospital Clínic of Barcelona
(author)
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Kamen, Diane L.Medical University of South Carolina
(author)
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Kalunian, Kenneth C.University of California, San Diego
(author)
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Jacobsen, SørenCopenhagen University Hospital
(author)
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Peschken, Christine A.University of Manitoba
(author)
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Askanase, AncaIndian Institute of Technology
(author)
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Hanly, John G.Dalhousie University
(author)
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Dalhousie UniversityHanyang University Hospital for Rheumatic Disease
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In:Arthritis Care and Research: Wiley74:4, s. 638-6472151-464X2151-4658
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Legge, Alexandra
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Kirkland, Susan
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Rockwood, Kennet ...
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Andreou, Panteli ...
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Bae, Sang Cheol
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Gordon, Caroline
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Bernatsky, Sasha
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Ginzler, Ellen M ...
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Fortin, Paul R.
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Gladman, Dafna D ...
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Urowitz, Murray ...
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Bruce, Ian N.
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Isenberg, David ...
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Rahman, Anisur
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Alarcón, Graciel ...
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Petri, Michelle
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Khamashta, Munth ...
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Manzi, Susan
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Zoma, Asad A.
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Aranow, Cynthia
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Ruiz-Irastorza, ...
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Inanc, Murat
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Kamen, Diane L.
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Karolinska Institutet