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Prediction of Hospi...
Prediction of Hospitalizations in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index
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- Legge, Alexandra (author)
- Dalhousie University
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- Kirkland, Susan (author)
- Dalhousie University
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- Rockwood, Kenneth (author)
- Dalhousie University
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- Andreou, Pantelis (author)
- Dalhousie University
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- Bae, Sang Cheol (author)
- Hanyang University Hospital for Rheumatic Disease
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- Gordon, Caroline (author)
- University of Birmingham
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- Romero-Diaz, Juanita (author)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
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- Sanchez-Guerrero, Jorge (author)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
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- Wallace, Daniel J. (author)
- University of California, Los Angeles
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- Bernatsky, Sasha (author)
- McGill University
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- Clarke, Ann E. (author)
- Cumming School of Medicine
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- Merrill, Joan T. (author)
- Oklahoma Medical Research Foundation
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- Ginzler, Ellen M. (author)
- SUNY Downstate Health Sciences University,Feinstein Institute for Medical Research
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- Fortin, Paul R. (author)
- Centre hospitalier universitaire de Québec
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- Gladman, Dafna D. (author)
- University of Toronto
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- Urowitz, Murray B. (author)
- University of Toronto
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- Bruce, Ian N. (author)
- University of Manchester
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- Isenberg, David A. (author)
- University College London,Indian Institute of Technology
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- Rahman, Anisur (author)
- University College London
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- Alarcón, Graciela S. (author)
- University of Alabama
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- Petri, Michelle (author)
- Johns Hopkins University School of Medicine
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- Khamashta, Munther A. (author)
- St Thomas' Hospital
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- Dooley, M. A. (author)
- University of North Carolina
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- Ramsey-Goldman, Rosalind (author)
- Northwestern University Feinberg School of Medicine
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- Manzi, Susan (author)
- Allegheny Health Network
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- Zoma, Asad A. (author)
- Hairmyres Hospital
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- Aranow, Cynthia (author)
- Feinstein Institute for Medical Research
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- Mackay, Meggan (author)
- Feinstein Institute for Medical Research
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- Ruiz-Irastorza, Guillermo (author)
- Biocruces Bizkaia Health Research Institute
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- Lim, S. Sam (author)
- Emory University
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Inanc, Murat (author)
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- van Vollenhoven, Ronald F. (author)
- Karolinska Institute
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- Jonsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Nived, Ola (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ramos-Casals, Manuel (author)
- Hospital Clínic of Barcelona
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- Kamen, Diane L. (author)
- Medical University of South Carolina
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- Kalunian, Kenneth C. (author)
- University of California, San Diego
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- Jacobsen, Søren (author)
- Copenhagen University Hospital
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- Peschken, Christine A. (author)
- University of Manitoba
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- Askanase, Anca (author)
- Indian Institute of Technology
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- Hanly, John G. (author)
- Dalhousie University
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(creator_code:org_t)
- 2022-02-17
- 2022
- English 10 s.
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In: Arthritis Care and Research. - : Wiley. - 2151-464X .- 2151-4658. ; 74:4, s. 638-647
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http://dx.doi.org/10...
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https://www.research...
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https://lup.lub.lu.s...
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Abstract
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- Objective: The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) predicts mortality and damage accrual in systemic lupus erythematosus (SLE), but its association with hospitalizations has not been described. Our objective was to estimate the association of baseline SLICC-FI values with future hospitalizations in the SLICC inception cohort. Methods: Baseline SLICC-FI scores were calculated. The number and duration of inpatient hospitalizations during follow-up were recorded. Negative binomial regression was used to estimate the association between baseline SLICC-FI values and the rate of hospitalizations per patient-year of follow-up. Linear regression was used to estimate the association of baseline SLICC-FI scores with the proportion of follow-up time spent in the hospital. Multivariable models were adjusted for relevant baseline characteristics. Results: The 1,549 patients with SLE eligible for this analysis were mostly female (88.7%), with a mean ± SD age of 35.7 ± 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9–1.5) at baseline. Mean ± SD baseline SLICC-FI was 0.17 ± 0.08. During mean ± SD follow-up of 7.2 ± 3.7 years, 614 patients (39.6%) experienced 1,570 hospitalizations. Higher baseline SLICC-FI values (per 0.05 increment) were associated with more frequent hospitalizations during follow-up, with an incidence rate ratio of 1.21 (95% confidence interval [95% CI] 1.13–1.30) after adjustment for baseline age, sex, glucocorticoid use, immunosuppressive use, ethnicity/location, SLE Disease Activity Index 2000 score, SLICC/American College of Rheumatology Damage Index score, and disease duration. Among patients with ≥1 hospitalization, higher baseline SLICC-FI values predicted a greater proportion of follow-up time spent hospitalized (relative rate 1.09 [95% CI 1.02–1.16]). Conclusion: The SLICC-FI predicts future hospitalizations among incident SLE patients, further supporting the SLICC-FI as a valid health measure in SLE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- By the author/editor
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Legge, Alexandra
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Kirkland, Susan
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Rockwood, Kennet ...
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Andreou, Panteli ...
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Bae, Sang Cheol
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Gordon, Caroline
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show more...
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Romero-Diaz, Jua ...
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Sanchez-Guerrero ...
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Wallace, Daniel ...
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Bernatsky, Sasha
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Clarke, Ann E.
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Merrill, Joan T.
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Ginzler, Ellen M ...
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Fortin, Paul R.
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Gladman, Dafna D ...
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Urowitz, Murray ...
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Bruce, Ian N.
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Isenberg, David ...
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Rahman, Anisur
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Alarcón, Graciel ...
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Petri, Michelle
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Khamashta, Munth ...
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Dooley, M. A.
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Ramsey-Goldman, ...
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Manzi, Susan
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Zoma, Asad A.
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, ...
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Lim, S. Sam
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Inanc, Murat
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van Vollenhoven, ...
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Jonsen, Andreas
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Nived, Ola
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Ramos-Casals, Ma ...
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Kamen, Diane L.
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Kalunian, Kennet ...
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Jacobsen, Søren
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Peschken, Christ ...
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Askanase, Anca
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Hanly, John G.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Arthritis Care a ...
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Lund University
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Karolinska Institutet