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Dolichoectasia and ...
Dolichoectasia and Small Vessel Disease in Young Patients with Transient Ischemic Attack and Stroke
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- Thijs, Vincent (författare)
- Austin Health,University of Melbourne
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- Grittner, Ulrike (författare)
- Charité - University Medicine Berlin
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- Fazekas, Franz (författare)
- Medical University of Graz
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- McCabe, Dominick J H (författare)
- Trinity College Dublin,University College London
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- Giese, Anne-Katrin (författare)
- University of Rostock
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- Kessler, Christof (författare)
- University of Greifswald
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- Martus, Peter (författare)
- University of Tübingen
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- Norrving, Bo (författare)
- Lund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Clinical Stroke Research Group,Lund University Research Groups
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- Ringelstein, Erich Bernd (författare)
- University of Münster
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- Schmidt, Reinhold (författare)
- Medical University of Graz
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- Tanislav, Christian (författare)
- Justus Liebig University Giessen
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- Putaala, Jukka (författare)
- Helsinki University Central Hospital,University of Helsinki
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- Tatlisumak, Turgut (författare)
- Helsinki University Central Hospital,Sahlgrenska University Hospital,Sahlgrenska Academy,University of Helsinki
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- von Sarnowski, Bettina (författare)
- University of Greifswald
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- Rolfs, Arndt (författare)
- University of Rostock
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- Enzinger, Christian (författare)
- Medical University of Graz
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(creator_code:org_t)
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- 2017
- 2017
- Engelska 7 s.
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Ingår i: Stroke. - 0039-2499. ; 48:9, s. 2361-2367
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and Purpose - We evaluated whether basilar dolichoectasia is associated with markers of cerebral small vessel disease in younger transient ischemic attack and ischemic stroke patients. Methods - We used data from the SIFAP1 study (Stroke in Young Fabry Patients), a large prospective, hospital-based, screening study for Fabry disease in young (<55 years) transient ischemic attack/stroke patients in whom detailed clinical data and brain MRI were obtained, and stroke subtyping with TOAST classification (Trial of ORG 10172 in Acute Stroke Treatment) was performed. Results - Dolichoectasia was found in 508 of 3850 (13.2%) of patients. Dolichoectasia was associated with older age (odds ratio per decade, 1.26; 95% confidence interval, 1.09-1.44), male sex (odds ratio, 1.96; 95% confidence interval, 1.59-2.42), and hypertension (odds ratio, 1.39; 95% confidence interval, 1.13-1.70). Dolichoectasia was more common in patients with small infarctions (33.9% versus 29.8% for acute lesions, P=0.065; 29.1% versus 16.5% for old lesions, P<0.001), infarct location in the brain stem (12.4% versus 6.9%, P<0.001), and in white matter (27.8% versus 21.1%, P=0.001). Microbleeds (16.3% versus 4.7%, P=0.001), higher grades of white matter hyperintensities (P<0.001), and small vessel disease subtype (18.1% versus 12.4%, overall P for differences in TOAST (P=0.018) were more often present in patients with dolichoectasia. Conclusions - Dolichoectasia is associated with imaging markers of small vessel disease and brain stem localization of acute and old infarcts in younger patients with transient ischemic attack and ischemic stroke.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Fabry disease
- hypertension
- infarction
- stroke
- white matter
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Stroke
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- Av författaren/redakt...
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Thijs, Vincent
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Grittner, Ulrike
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Fazekas, Franz
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McCabe, Dominick ...
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Giese, Anne-Katr ...
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Kessler, Christo ...
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visa fler...
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Martus, Peter
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Norrving, Bo
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Ringelstein, Eri ...
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Schmidt, Reinhol ...
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Tanislav, Christ ...
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Putaala, Jukka
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Tatlisumak, Turg ...
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von Sarnowski, B ...
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Rolfs, Arndt
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Enzinger, Christ ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Stroke
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Lunds universitet