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  • Linton, Jonathan D. (author)

Flow of energy in the outer retina in darkness and in light

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-05-05
  • Proceedings of the National Academy of Sciences,2010

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:7b81c2eb-729f-418e-9993-7dd29da1337f
  • https://lup.lub.lu.se/record/1617703URI
  • https://doi.org/10.1073/pnas.1002471107DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Structural features of neurons create challenges for effective production and distribution of essential metabolic energy. We investigated how metabolic energy is distributed between cellular compartments in photoreceptors. In avascular retinas, aerobic production of energy occurs only in mitochondria that are located centrally within the photoreceptor. Our findings indicate that metabolic energy flows from these central mitochondria as phosphocreatine toward the photoreceptor's synaptic terminal in darkness. In light, it flows in the opposite direction as ATP toward the outer segment. Consistent with this model, inhibition of creatine kinase in avascular retinas blocks synaptic transmission without influencing outer segment activity. Our findings also reveal how vascularization of neuronal tissue can influence the strategies neurons use for energy management. In vascularized retinas, mitochondria in the synaptic terminals of photoreceptors make neurotransmission less dependent on creatine kinase. Thus, vasculature of the tissue and the intracellular distribution of mitochondria can play key roles in setting the strategy for energy distribution in neurons.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Holzhausen, Lars C. (author)
  • Babai, Norbert (author)
  • Song, Hongman (author)
  • Miyagishima, Kiyoharu J. (author)
  • Stearns, George W. (author)
  • Lindsay, Ken (author)
  • Wei, Junhua (author)
  • Chertov, Andrei O. (author)
  • Peters, Theo A. (author)
  • Caffé, RomeoLund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)oft-rca (author)
  • Pluk, Helma (author)
  • Seeliger, Mathias W. (author)
  • Tanimoto, Naoyuki (author)
  • Fong, Kimberly (author)
  • Bolton, Laura (author)
  • Kuok, Denise L. T. (author)
  • Sweet, Ian R. (author)
  • Bartoletti, Theodore M. (author)
  • Radu, Roxana A. (author)
  • Travis, Gabriel H. (author)
  • Zagotta, Willam N. (author)
  • Townes-Anderson, Ellen (author)
  • Parker, Ed (author)
  • Van der Zee, Catharina E. E. M. (author)
  • Sampath, Alapakkam P. (author)
  • Sokolov, Maxim (author)
  • Thoreson, Wallace B. (author)
  • Hurley, James B. (author)
  • Oftalmologi, LundSektion IV (creator_code:org_t)

Related titles

  • In:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences107:19, s. 8599-86041091-64900027-8424

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