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Flow of energy in t...
Flow of energy in the outer retina in darkness and in light
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Linton, Jonathan D. (author)
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Holzhausen, Lars C. (author)
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Babai, Norbert (author)
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Song, Hongman (author)
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Miyagishima, Kiyoharu J. (author)
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Stearns, George W. (author)
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Lindsay, Ken (author)
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Wei, Junhua (author)
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Chertov, Andrei O. (author)
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Peters, Theo A. (author)
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- Caffé, Romeo (author)
- Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Pluk, Helma (author)
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Seeliger, Mathias W. (author)
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Tanimoto, Naoyuki (author)
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Fong, Kimberly (author)
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Bolton, Laura (author)
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Kuok, Denise L. T. (author)
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Sweet, Ian R. (author)
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Bartoletti, Theodore M. (author)
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Radu, Roxana A. (author)
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Travis, Gabriel H. (author)
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Zagotta, Willam N. (author)
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Townes-Anderson, Ellen (author)
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Parker, Ed (author)
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Van der Zee, Catharina E. E. M. (author)
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Sampath, Alapakkam P. (author)
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Sokolov, Maxim (author)
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Thoreson, Wallace B. (author)
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Hurley, James B. (author)
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(creator_code:org_t)
- 2010-05-05
- 2010
- English.
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In: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 107:19, s. 8599-8604
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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Abstract
Subject headings
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- Structural features of neurons create challenges for effective production and distribution of essential metabolic energy. We investigated how metabolic energy is distributed between cellular compartments in photoreceptors. In avascular retinas, aerobic production of energy occurs only in mitochondria that are located centrally within the photoreceptor. Our findings indicate that metabolic energy flows from these central mitochondria as phosphocreatine toward the photoreceptor's synaptic terminal in darkness. In light, it flows in the opposite direction as ATP toward the outer segment. Consistent with this model, inhibition of creatine kinase in avascular retinas blocks synaptic transmission without influencing outer segment activity. Our findings also reveal how vascularization of neuronal tissue can influence the strategies neurons use for energy management. In vascularized retinas, mitochondria in the synaptic terminals of photoreceptors make neurotransmission less dependent on creatine kinase. Thus, vasculature of the tissue and the intracellular distribution of mitochondria can play key roles in setting the strategy for energy distribution in neurons.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Keyword
- energy metabolism
- phototransduction
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Linton, Jonathan ...
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Holzhausen, Lars ...
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Babai, Norbert
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Song, Hongman
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Miyagishima, Kiy ...
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Stearns, George ...
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show more...
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Lindsay, Ken
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Wei, Junhua
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Chertov, Andrei ...
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Peters, Theo A.
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Caffé, Romeo
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Pluk, Helma
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Seeliger, Mathia ...
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Tanimoto, Naoyuk ...
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Fong, Kimberly
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Bolton, Laura
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Kuok, Denise L. ...
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Sweet, Ian R.
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Bartoletti, Theo ...
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Radu, Roxana A.
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Travis, Gabriel ...
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Zagotta, Willam ...
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Townes-Anderson, ...
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Parker, Ed
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Van der Zee, Cat ...
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Sampath, Alapakk ...
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Sokolov, Maxim
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Thoreson, Wallac ...
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Hurley, James B.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Ophthalmology
- Articles in the publication
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Proceedings of t ...
- By the university
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Lund University