Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

Here, we characterize a subset of ILC3s that express Neuropilin1 (NRP1) and are present in lymphoid tissues, but not in the peripheral blood or skin. NRP1+ group 3 innate lymphoid cells (ILC3s) display in vitro lymphoid tissue inducer (LTi) activity. In agreement with this, NRP1+ ILC3s are mainly located in proximity to high endothelial venules (HEVs) and express cell surface molecules involved in lymphocyte migration in secondary lymphoid tissues via HEVs. NRP1 was also expressed on mouse fetal LTi cells, indicating that NRP1 is a conserved marker for LTi cells. Human NRP1+ ILC3s are primed cells because they express CD45RO and produce higher amounts of cytokines than NRP1− cells, which express CD45RA. The NRP1 ligand vascular endothelial growth factor A (VEGF-A) served as a chemotactic factor for NRP1+ ILC3s. NRP1+ ILC3s are present in lung tissues from smokers and patients with chronic obstructive pulmonary disease, suggesting a role in angiogenesis and/or the initiation of ectopic pulmonary lymphoid aggregates.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
chemotaxis
HEVs
high endothelial venues
human innate lymphoid cells 3
ILC3
LA
LTi
lymphoid tissue inducer cells
neuropilin-1
NRP1
smoke-induced pulmonary lymphoid aggregates
vascular endothelial growth factor A
VEGF-A

Björklund, Åsa K.Karolinska Institute (author)
Mjösberg, JennyKarolinska Institutet,Karolinska Institute (author)
Erjefält, Jonas S.Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups(Swepub:lu)mphy-jer (author)
Cornelissen, Anne S.University of Amsterdam (author)
Ros, Xavier RomeroUniversity of Amsterdam (author)
Bal, Suzanne M.University of Amsterdam (author)
Koning, Jasper J.Vrije Universiteit Amsterdam (author)
Mebius, Reina E.Vrije Universiteit Amsterdam (author)
Mori, MichikoLund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups(Swepub:lu)med-mhm (author)
Bruchard, MelanieUniversity of Amsterdam (author)
Blom, BiancaUniversity of Amsterdam (author)
Spits, HergenUniversity of Amsterdam (author)
Karolinska InstituteUniversity of Amsterdam (creator_code:org_t)

By the author/editor: Shikhagaie, Medy ...; Björklund, Åsa K ...; Mjösberg, Jenny; Erjefält, Jonas ...; Cornelissen, Ann ...; Ros, Xavier Rome ...; show more...; Bal, Suzanne M.; Koning, Jasper J ...; Mebius, Reina E.; Mori, Michiko; Bruchard, Melani ...; Blom, Bianca; Spits, Hergen; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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