Sleep duration and risk of cancer incidence and mortality : A pooled analysis of six population-based cohorts in Japan

Sleep duration is emerging as an important modifiable risk factor for morbidity and mortality. We assessed the association between sleep duration and cancer incidence and mortality among Japanese adults using data from six population-based cohorts with 271 694 participants. During a total follow-up period of about 5.9 million person-years, we identified 40 751 incident cancer cases and 18 323 cancer deaths. We computed study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression models and pooled the estimates using random-effects meta-analysis. Sleep duration of ≥10 hours (vs 7 hours) was associated with increased risk of cancer incidence among women (HR 1.19, 95% CI 1.02-1.38), but not men, and increased risk of cancer mortality among men (HR 1.18, 95% CI 1.00-1.39) and women (HR 1.44, 95% CI 1.20-1.73). Sleep duration of ≤5 hours (vs 7 hours) was not associated with cancer incidence and mortality. However, among postmenopausal women, sleep durations of both ≤5 and ≥10 hours (vs 7 hours) were associated with an increased risk of cancer mortality. Among Japanese adults, sleep duration of ≥10 hours is associated with increased risk of cancer incidence and mortality among women and cancer mortality among men.

Abe, Sarah KrullNational Cancer Center Tokyo (författare)
Svensson, ThomasLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,National Cancer Center Tokyo,Kanagawa University of Human Services,Skåne University Hospital,University of Tokyo(Swepub:lu)th4123sv (författare)
Sawada, NorieNational Cancer Center Tokyo (författare)
Tsugane, ShoichiroNational Cancer Center Tokyo (författare)
Wada, KeikoGifu University (författare)
Nagata, ChisatoGifu University (författare)
Kimura, TakashiHokkaido University (författare)
Tamakoshi, AkikoHokkaido University (författare)
Sugawara, YumiTohoku University (författare)
Tsuji, IchiroTohoku University (författare)
Ito, HidemiAichi Cancer Center Research Institute (författare)
Kitamura, TetsuhisaOsaka University (författare)
Sakata, RitsuRadiation Effects Research Foundation Hiroshima (författare)
Mizoue, TetsuyaNational Center for Global Health and Medicine (författare)
Matsuo, KeitaroAichi Cancer Center Research Institute (författare)
Tanaka, KeitaroSaga University (författare)
Lin, YingsongAichi Medical University (författare)
Inoue, ManamiNational Cancer Center Tokyo (författare)
National Cancer Center TokyoKardiovaskulär forskning - hypertoni (creator_code:org_t)
Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan

Ingår i:International Journal of Cancer: Wiley151:7, s. 1068-10800020-71361097-0215

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