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Progression analysi...
Progression analysis versus traditional methods to quantify slowing of disease progression in Alzheimer’s disease
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- Jönsson, Linus (författare)
- Karolinska Institutet,Karolinska Institute
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- Ivkovic, Milana (författare)
- Novo Nordisk A/S
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- Atri, Alireza (författare)
- Harvard Medical School,Banner Sun Health Research Institute
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- Handels, Ron (författare)
- Karolinska Institutet,Karolinska Institute,Maastricht University
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- Gustavsson, Anders (författare)
- Karolinska Institute
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- Hahn-Pedersen, Julie Hviid (författare)
- Novo Nordisk A/S
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- León, Teresa (författare)
- Novo Nordisk A/S
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Lilja, Mathias (författare)
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- Gundgaard, Jens (författare)
- Novo Nordisk A/S
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- Raket, Lars Lau (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Novo Nordisk A/S
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Alzheimer's Research and Therapy. - 1758-9193. ; 16:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
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- Background: The clinical meaningfulness of the effects of recently approved disease-modifying treatments (DMT) in Alzheimer’s disease is under debate. Available evidence is limited to short-term effects on clinical rating scales which may be difficult to interpret and have limited intrinsic meaning to patients. The main value of DMTs accrues over the long term as they are expected to cause a delay or slowing of disease progression. While awaiting such evidence, the translation of short-term effects to time delays or slowing of progression could offer a powerful and readily interpretable representation of clinical outcomes. Methods: We simulated disease progression trajectories representing two arms, active and placebo, of a hypothetical clinical trial of a DMT. The placebo arm was simulated based on estimated mean trajectories of clinical dementia rating scale–sum of boxes (CDR-SB) recordings from amyloid-positive subjects with mild cognitive impairment (MCI) from Alzheimer’s Disease Neuroimaging Initiative (ADNI). The active arm was simulated to show an average slowing of disease progression versus placebo of 20% at each visit. The treatment effects in the simulated trials were estimated with a progression model for repeated measures (PMRM) and a mixed model for repeated measures (MMRM) for comparison. For PMRM, the treatment effect is expressed in units of time (e.g., days) and for MMRM in units of the outcome (e.g., CDR-SB points). PMRM results were implemented in a health economics Markov model extrapolating disease progression and death over 15 years. Results: The PMRM model estimated a 19% delay in disease progression at 18 months and 20% (~ 7 months delay) at 36 months, while the MMRM model estimated a 25% reduction in CDR-SB (~ 0.5 points) at 36 months. The PMRM model had slightly greater power compared to MMRM. The health economic model based on the estimated time delay suggested an increase in life expectancy (10 months) without extending time in severe stages of disease. Conclusion: PMRM methods can be used to estimate treatment effects in terms of slowing of progression which translates to time metrics that can be readily interpreted and appreciated as meaningful outcomes for patients, care partners, and health care practitioners.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer’s disease
- Disease progression
- Statistical model
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Jönsson, Linus
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Ivkovic, Milana
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Atri, Alireza
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Handels, Ron
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Gustavsson, Ande ...
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Hahn-Pedersen, J ...
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visa fler...
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León, Teresa
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Lilja, Mathias
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Gundgaard, Jens
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Raket, Lars Lau
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Alzheimer's Rese ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet