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Diffusion Tensor Im...
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Chapman, Christopher H.
(författare)
Diffusion Tensor Imaging of Normal-Appearing White Matter as Biomarker for Radiation-Induced Late Delayed Cognitive Decline
- Artikel/kapitelEngelska2012
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:7e15e2a2-c181-45f9-9af5-6bf0c73491e2
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https://lup.lub.lu.se/record/2587640URI
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https://doi.org/10.1016/j.ijrobp.2011.01.068DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Purpose: To determine whether early assessment of cerebral white matter degradation can predict late delayed cognitive decline after radiotherapy (RT). Methods and Materials: Ten patients undergoing conformal fractionated brain RT participated in a prospective diffusion tensor magnetic resonance imaging study. Magnetic resonance imaging studies were acquired before RT, at 3 and 6 weeks during RT, and 10, 30, and 78 weeks after starting RT. The diffusivity variables in the parahippocampal cingulum bundle and temporal lobe white matter were computed. A quality-of-life survey and neuro-cognitive function tests were administered before and after RT at the magnetic resonance imaging follow-up visits. Results: In both structures, longitudinal diffusivity (lambda(parallel to)) decreased and perpendicular diffusivity (lambda(perpendicular to)) increased after RT, with early changes correlating to later changes (p < .05). The radiation dose correlated with an increase in cingulum lambda(perpendicular to) at 3 weeks, and patients with >50% of cingula volume receiving >12 Gy had a greater increase in lambda(perpendicular to) at 3 and 6 weeks (p < .05). The post-RT changes in verbal recall scores correlated linearly with the late changes in cingulum lambda(parallel to) (30 weeks, p < .02). Using receiver operating characteristic curves, early cingulum lambda(parallel to) changes predicted for post-RT changes in verbal recall scores (3 and 6 weeks, p < .05). The neurocognitive test scores correlated significantly with the quality-of-life survey results. Conclusions: The correlation between early diffusivity changes in the parahippocampal cingulum and the late decline in verbal recall suggests that diffusion tensor imaging might be useful as a biomarker for predicting late delayed cognitive decline. (C) 2012 Elsevier Inc.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nagesh, Vijaya
(författare)
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Sundgren, PiaLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-psu
(författare)
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Buchtel, Henry
(författare)
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Chenevert, Thomas L.
(författare)
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Junck, Larry
(författare)
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Lawrence, Theodore S.
(författare)
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Tsien, Christina I.
(författare)
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Cao, Yue
(författare)
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Diagnostisk radiologi, LundSektion V
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Radiation Oncology, Biology, Physics: Elsevier BV82:5, s. 2033-20400360-3016
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