Search: onr:"swepub:oai:lup.lub.lu.se:7e364147-7e27-4972-ae18-4074add3afed" >
Antigen-binding sit...
-
Wingren, ChristerLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH
(author)
Antigen-binding sites dominate the surface properties of IgG antibodies
- Article/chapterEnglish1995
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:7e364147-7e27-4972-ae18-4074add3afed
-
https://lup.lub.lu.se/record/126540URI
-
https://doi.org/10.1016/0161-5890(95)00044-FDOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:1927709URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
A new technique, liquid-liquid partition chromatography in an aqueous polyethylene glycol-dextran two-phase system, was used to detect differences in surface properties of antibodies with different antigen-binding sites. Employing well-characterized monoclonal IgG antibodies and Fab and Fc fragments thereof as well as chimeric IgG antibodies we found a remarkable relationship between structure of the antibody combining site and chromatographic behaviour. The surface properties of the IgG antibodies were dominated by those of its antigen-binding regions. In addition, our results indicated that the constant parts of the IgGs form similar scaffoldings, on to which CDRs of variable shapes and sizes are interspaced and constitute the major dominant differences in exposed surface properties.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Hansson, Ulla-Britt
(author)
-
Magnusson, Carl G.M
(author)
-
Ohlin, MatsLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)immt-moh
(author)
-
Institutionen för immunteknologiInstitutioner vid LTH
(creator_code:org_t)
Related titles
-
In:Molecular Immunology32:11, s. 819-8271872-91420161-5890
Internet link
Find in a library
To the university's database