Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale

Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.

Leonardo Cespedes, Carlos (författare)
Becerra, Jose (författare)
Davila, Marcelo (författare)
Sterner, OlovLund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ok2-ost (författare)
Centrum för analys och syntesKemiska institutionen (creator_code:org_t)

Ingår i:Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences: Walter de Gruyter GmbH70:3-4, s. 97-1020939-5075
Ingår i:Zeitschrift für Naturforschung C: Walter de Gruyter GmbH70:3-4, s. 97-1021865-7125

Av författaren/redakt...: Aqueveque, Pedro; Leonardo Cespede ...; Becerra, Jose; Davila, Marcelo; Sterner, Olov

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