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Reasons for Discont...
Reasons for Discontinuing Active Surveillance : Assessment of 21 Centres in 12 Countries in the Movember GAP3 Consortium
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- Van Hemelrijck, Mieke (author)
- King's College London
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- Ji, Xi (author)
- Cleveland Clinic Foundation
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- Helleman, Jozien (author)
- Erasmus University Medical Center
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- Roobol, Monique J. (author)
- Erasmus University Medical Center
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- van der Linden, Wim (author)
- PMS Research Paris Medical Imaging Systems Group (Medisys)
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Nieboer, Daan (author)
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- Bangma, Chris H. (author)
- Erasmus University Medical Center
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- Frydenberg, Mark (author)
- Monash University
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Rannikko, Antti (author)
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- Lee, Lui S. (author)
- Singapore General Hospital
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- Gnanapragasam, Vincent J. (author)
- University of Cambridge
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- Kattan, Mike W. (author)
- Cleveland Clinic Foundation
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Trock, Bruce (creator_code:cre_t)
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Ehdaie, Behfar (creator_code:cre_t)
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Carroll, Peter (creator_code:cre_t)
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Filson, Christopher (creator_code:cre_t)
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Kim, Jeri (creator_code:cre_t)
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Logothetis, Christopher (creator_code:cre_t)
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Morgan, Todd (creator_code:cre_t)
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Klotz, Laurence (creator_code:cre_t)
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Pickles, Tom (creator_code:cre_t)
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Hyndman, Eric (creator_code:cre_t)
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Moore, Caroline M. (creator_code:cre_t)
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Gnanapragasam, Vincent (creator_code:cre_t)
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Van Hemelrijck, Mieke (creator_code:cre_t)
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Dasgupta, Prokar (creator_code:cre_t)
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Bangma, Chris (creator_code:cre_t)
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Roobol, Monique (creator_code:cre_t)
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Villers, Arnauld (creator_code:cre_t)
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Rannikko, Antti (creator_code:cre_t)
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Valdagni, Riccardo (creator_code:cre_t)
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Perry, Antoinette (creator_code:cre_t)
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Hugosson, Jonas (creator_code:cre_t)
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Rubio-Briones, Jose (creator_code:cre_t)
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- Bjartell, Anders (creator_code:cre_t)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups,Skåne University Hospital
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Hefermehl, Lukas (creator_code:cre_t)
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Lui Shiong, Lee (creator_code:cre_t)
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Frydenberg, Mark (creator_code:cre_t)
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Kakehi, Yoshiyuki (creator_code:cre_t)
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Ha Chung, Byung (creator_code:cre_t)
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van der Kwast, Theo (creator_code:cre_t)
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Obbink, Henk (creator_code:cre_t)
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van der Linden, Wim (creator_code:cre_t)
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Hulsen, Tim (creator_code:cre_t)
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de Jonge, Cees (creator_code:cre_t)
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Kattan, Mike (creator_code:cre_t)
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Xinge, Ji (creator_code:cre_t)
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- Löfgren, Annica (creator_code:cre_t)
- Skåne University Hospital
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(creator_code:org_t)
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- Elsevier BV, 2019
- 2019
- English 9 s.
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In: European Urology. - : Elsevier BV. - 0302-2838. ; 75:3, s. 523-531
- Related links:
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http://dx.doi.org/10...
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https://helda.helsin...
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Abstract
Subject headings
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- Background: Careful assessment of the reasons for discontinuation of active surveillance (AS) is required for men with prostate cancer (PCa). Objective: Using Movember's Global Action Plan Prostate Cancer Active Surveillance initiative (GAP3) database, we report on reasons for AS discontinuation. Design, setting, and participants: We compared data from 10 296 men on AS from 21 centres across 12 countries. Outcome measurements and statistical analysis: Cumulative incidence methods were used to estimate the cumulative incidence rates of AS discontinuation. Results and limitations: During 5-yr follow-up, 27.5% (95% confidence interval [CI]: 26.4–28.6%) men showed signs of disease progression, 12.8% (95% CI: 12.0–13.6%) converted to active treatment without evidence of progression, 1.7% (95% CI: 1.5–2.0%) continued to watchful waiting, and 1.7% (95% CI: 1.4–2.1%) died from other causes. Of the 7049 men who remained on AS, 2339 had follow-up for >5 yr, 4561 had follow-up for <5 yr, and 149 were lost to follow-up. Cumulative incidence of progression was 27.5% (95% CI: 26.4–28.6%) at 5 yr and 38.2% (95% CI: 36.7–39.9%) at 10 yr. A limitation is that not all centres were included due to limited information on the reason for discontinuation and limited follow-up. Conclusions: Our descriptive analyses of current AS practices worldwide showed that 43.6% of men drop out of AS during 5-yr follow-up, mainly due to signs of disease progression. Improvements in selection tools for AS are thus needed to correctly allocate men with PCa to AS, which will also reduce discontinuation due to conversion to active treatment without evidence of disease progression. Patient summary: Our assessment of a worldwide database of men with prostate cancer (PCa) on active surveillance (AS) shows that 43.6% drop out of AS within 5 yr, mainly due to signs of disease progression. Better tools are needed to select and monitor men with PCa as part of AS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Active surveillance
- Discontinuation
- Prostate cancer
- Worldwide
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Van Hemelrijck, ...
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Ji, Xi
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Helleman, Jozien
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Roobol, Monique ...
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van der Linden, ...
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Nieboer, Daan
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show more...
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Bangma, Chris H.
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Frydenberg, Mark
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Rannikko, Antti
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Lee, Lui S.
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Gnanapragasam, V ...
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Kattan, Mike W.
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Trock, Bruce
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Ehdaie, Behfar
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Carroll, Peter
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Filson, Christop ...
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Kim, Jeri
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Logothetis, Chri ...
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Morgan, Todd
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Klotz, Laurence
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Pickles, Tom
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Hyndman, Eric
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Moore, Caroline ...
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Gnanapragasam, V ...
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Dasgupta, Prokar
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Bangma, Chris
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Roobol, Monique
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Villers, Arnauld
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Valdagni, Riccar ...
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Perry, Antoinett ...
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Hugosson, Jonas
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Rubio-Briones, J ...
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Bjartell, Anders
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Hefermehl, Lukas
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Lui Shiong, Lee
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Kakehi, Yoshiyuk ...
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Ha Chung, Byung
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van der Kwast, T ...
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Obbink, Henk
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Hulsen, Tim
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de Jonge, Cees
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Kattan, Mike
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Xinge, Ji
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Löfgren, Annica
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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European Urology
- By the university
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Lund University