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The TLR2 Antagonist...
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Koymans, Kirsten JUniversity Medical Center Utrecht
(författare)
The TLR2 Antagonist Staphylococcal Superantigen-Like Protein 3 Acts as a Virulence Factor to Promote Bacterial Pathogenicity in vivo
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-09-01
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S. Karger AG,2017
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:800918f8-71ce-4b94-b60c-0319c41db9d9
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https://lup.lub.lu.se/record/800918f8-71ce-4b94-b60c-0319c41db9d9URI
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https://doi.org/10.1159/000479100DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Toll-like receptor (TLR) signaling is important in the initiation of immune responses and subsequent instigation of adaptive immunity. TLR2 recognizes bacterial lipoproteins and plays a central role in the host defense against bacterial infections, including those caused by Staphylococcus aureus. Many studies have demonstrated the importance of TLR2 in murine S. aureus infection. S. aureus evades TLR2 activation by secreting two proteins, staphylococcal superantigen-like protein 3 (SSL3) and 4 (SSL4). In this study, we demonstrate that antibodies against SSL3 and SSL4 are found in healthy individuals, indicating that humans are exposed to these proteins during S. aureus colonization or infection. To investigate the TLR2-antagonistic properties of SSL3 and SSL4, we compared the infection with wild-type and SSL3/4 knockout S. aureus strains in an intravenous murine infection model. Direct evaluation of the contribution of SSL3/4 to infection pathogenesis was hindered by the fact that the SSLs were not expressed in the murine system. To circumvent this limitation, an SSL3-overproducing strain (pLukM-SSL3) was generated, resulting in constitutive expression of SSL3. pLukM-SSL3 exhibited increased virulence compared to the parental strain in a murine model that was found to be TLR2 dependent. Altogether, these data indicate that SSL3 contributes to S. aureus virulence in vivo.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Goldmann, OliverHelmholtz Centre for Infection Research
(författare)
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Karlsson, Christofer A QLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups(Swepub:lu)medk-cka
(författare)
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Sital, WiedjaiUniversity Medical Center Utrecht
(författare)
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Thänert, RobertHelmholtz Centre for Infection Research
(författare)
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Bisschop, AdindaUniversity Medical Center Utrecht
(författare)
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Vrieling, ManoukUniversity Medical Center Utrecht
(författare)
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Malmström, JohanLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,epIgG,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,CEBMMS PI,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund(Swepub:lu)medk-jma
(författare)
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Kessel, Kok P.M.University Medical Center Utrecht
(författare)
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de Haas, Carla J CUniversity Medical Center Utrecht
(författare)
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van Strijp, Jos A.G.University Medical Center Utrecht
(författare)
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Medina, EvaHelmholtz Centre for Infection Research
(författare)
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University Medical Center UtrechtHelmholtz Centre for Infection Research
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Innate Immunity: S. Karger AG9, s. 561-5731662-811X1662-8128
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Koymans, Kirsten ...
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Goldmann, Oliver
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Karlsson, Christ ...
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Sital, Wiedjai
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Thänert, Robert
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Bisschop, Adinda
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visa fler...
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Vrieling, Manouk
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Malmström, Johan
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Kessel, Kok P.M.
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de Haas, Carla J ...
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van Strijp, Jos ...
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Medina, Eva
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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Journal of Innat ...
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Lunds universitet