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Unilateral traumati...
Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats
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- Bakalkin, Georgy (författare)
- Uppsala universitet,Uppsala University,Institutionen för farmaceutisk biovetenskap
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- Nosova, Olga (författare)
- Uppsala universitet,Uppsala University,Institutionen för farmaceutisk biovetenskap
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- Sarkisyan, Daniil (författare)
- Uppsala universitet,Uppsala University,Institutionen för farmaceutisk biovetenskap
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- Hallberg, Mathias, 1971- (författare)
- Uppsala universitet,Uppsala University,Institutionen för farmaceutisk biovetenskap
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- Zhang, Mengliang (författare)
- Lund University,Lunds universitet,Neuronano Research Center (NRC),Forskargrupper vid Lunds universitet,Lund University Research Groups,University of Southern Denmark,Univ Southern Denmark, Dept Mol Med, Odense, Denmark.;Lund Univ, Dept Expt Med Sci, Neuronano Res Ctr, Lund, Sweden.
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- Schouenborg, Jens (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Neurofysiologi,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),Other operations, LTH,Faculty of Engineering, LTH,Neurophysiology,Lund University Research Groups,Lund Univ, Dept Expt Med Sci, Neuronano Res Ctr, Lund, Sweden.
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- Marklund, Niklas (författare)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUBIN Lab- Lunds laboratorium för neurokirurgisk hjärnskadeforskning,Forskargrupper vid Lunds universitet,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,LUBIN Lab- Lund Brain Injury laboratory for Neurosurgical research,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Neurosurg, Lund, Sweden.
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- Watanabe, Hiroyuki (författare)
- Uppsala universitet,Uppsala University,Institutionen för farmaceutisk biovetenskap
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(creator_code:org_t)
- 2021-05-22
- 2021
- Engelska.
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Ingår i: Experimental Brain Research. - : Springer Science and Business Media LLC. - 0014-4819 .- 1432-1106. ; 239:7, s. 2221-2232
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Traumatic brain injury and stroke result in hemiplegia, hemiparesis, and asymmetry in posture. The effects are mostly contralateral; however, ipsilesional deficits may also develop. We here examined whether ablation brain injury and controlled cortical impact (CCI), a rat model of clinical focal traumatic brain injury, both centered over the left or right sensorimotor cortex, induced hindlimb postural asymmetry (HL-PA) with contralesional or ipsilesional limb flexion. The contralesional hindlimb was flexed after left or right side ablation injury. In contrast, both the left and right CCI unexpectedly produced HL-PA with flexion on left side. The flexion persisted after complete spinal cord transection suggesting that CCI triggered neuroplastic processes in lumbar neural circuits enabling asymmetric muscle contraction. Left limb flexion was exhibited under pentobarbital anesthesia. However, under ketamine anesthesia, the body of the left and right CCI rats bent laterally in the coronal plane to the ipsilesional side suggesting that the left and right injury engaged mirror-symmetrical motor pathways. Thus, the effects of the left and right CCI on HL-PA were not mirror-symmetrical in contrast to those of the ablation brain injury, and to the left and right CCI produced body bending. Ipsilateral effects of the left CCI on HL-PA may be mediated by a lateralized motor pathway that is not affected by the left ablation injury. Alternatively, the left-side-specific neurohormonal mechanism that signals from injured brain to spinal cord may be activated by both the left and right CCI but not by ablation injury.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Contralateral response
- Ipsilateral response
- Postural asymmetry
- Stroke
- Traumatic brain injury
- Traumatic brain injury
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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