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Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination
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- Gao, Yu (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Cai, Curtis (författare)
- Karolinska Institutet
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- Wullimann, David (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Niessl, Julia (författare)
- Karolinska Institutet
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- Rivera-Ballesteros, Olga (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Chen, Puran (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Lange, Joshua (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Cuapio, Angelica (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Blennow, Ola (författare)
- Karolinska Institutet
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- Hansson, Lotta (författare)
- Karolinska Institutet
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- Mielke, Stephan (författare)
- Karolinska Institutet
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- Nowak, Piotr (författare)
- Karolinska Institutet,Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institute, Stockholm, Sweden
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- Vesterbacka, Jan (författare)
- Karolinska Institutet
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- Akber, Mira (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Perez-Potti, Andre (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Sekine, Takuya (författare)
- Karolinska Institutet
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- Müller, Thomas R. (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Boulouis, Caroline (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Kammann, Tobias (författare)
- Karolinska Institutet
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- Parrot, Tiphaine (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Muvva, Jagadeeswara Rao (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Sobkowiak, Michal (författare)
- Karolinska Institutet
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- Healy, Katie (författare)
- Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Bogdanovic, Gordana (författare)
- Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
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- Muschiol, Sandra (författare)
- Karolinska Institutet
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- Söderdahl, Gunnar (författare)
- Department of Transplantation, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
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- Österborg, Anders (författare)
- Karolinska Institutet
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- Hellgren, Fredrika (författare)
- Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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- Grifoni, Alba (författare)
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, CA, La Jolla, United States
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- Weiskopf, Daniela (författare)
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, CA, La Jolla, United States
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- Sette, Alessandro (författare)
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, CA, La Jolla, United States; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), CA, La Jolla, United States
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- Loré, Karin (författare)
- Karolinska Institutet
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- Sällberg Chen, Margaret (författare)
- Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Ljungman, Per (författare)
- Karolinska Institutet
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- Sandberg, Johan K. (författare)
- Karolinska Institutet
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- Smith, C.I. Edvard (författare)
- Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital Huddinge, Stockholm, Sweden
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- Bergman, Peter (författare)
- Karolinska Institutet
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- Ljunggren, Hans-Gustaf (författare)
- Karolinska Institutet
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- Aleman, Soo (författare)
- Karolinska Institutet
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- Buggert, Marcus (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier, 2022
- Engelska.
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Ingår i: Immunity. - : Elsevier. - 1074-7613 .- 1097-4180. ; 55:9, s. 1732-1746.e5
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and patients with various forms of immunodeficiencies. Impaired vaccine-induced cell-mediated immunity was observed in many immunocompromised patients, particularly in solid-organ transplant and chronic lymphocytic leukemia patients. Notably, individuals with an inherited lack of mature B cells, i.e., X-linked agammaglobulinemia (XLA) displayed highly functional spike-specific T cell responses. Single-cell RNA-sequencing further revealed that mRNA vaccination induced a broad functional spectrum of spike-specific CD4+ and CD8+ T cells in healthy individuals and patients with XLA. These responses were founded on polyclonal repertoires of CD4+ T cells and robust expansions of oligoclonal effector-memory CD45RA+ CD8+ T cells with stem-like characteristics. Collectively, our data provide the functional continuum of SARS-CoV-2-specific T cell responses post-mRNA vaccination, highlighting that cell-mediated immunity is of variable functional quality across immunodeficiency syndromes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- COVID-19
- mRNA vaccine
- SARS-CoV-2
- T cells
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)