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Maternal Exposure t...
Maternal Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Male Reproductive Function in Young Adulthood : Combined Exposure to Seven PFAS
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- Hærvig, Katia Keglberg (author)
- Copenhagen University Hospital
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- Petersen, Kajsa Ugelvig (author)
- Copenhagen University Hospital
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- Hougaard, Karin Sørig (author)
- The National Research Centre for the Working Environment,University of Copenhagen
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- Lindh, Christian (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Ramlau-Hansen, Cecilia Høst (author)
- Aarhus University
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- Toft, Gunnar (author)
- Aarhus University Hospital
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproduktionsmedicin, Malmö,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups,Reproductive medicine, Malmö
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- Høyer, Birgit Bjerre (author)
- Vejle Hospital
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- Flachs, Esben Meulengracht (author)
- Copenhagen University Hospital
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- Bonde, Jens Peter (author)
- University of Copenhagen,Copenhagen University Hospital
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- Tøttenborg, Sandra Søgaard (author)
- Copenhagen University Hospital,University of Copenhagen
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(creator_code:org_t)
- 2022
- 2022
- English 1 s.
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In: Environmental Health Perspectives. - 1552-9924. ; 130:10, s. 107001-107001
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Abstract
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- BACKGROUND: Concerns remain about the human reproductive toxicity of the widespread per- and polyfluoroalkyl substances (PFAS) during early stages of development. OBJECTIVES: We examined associations between maternal plasma PFAS levels during early pregnancy and male offspring reproductive function in adulthood. METHODS: The study included 864 young men (age range:18.9-21.2 y) from the Fetal Programming of Semen Quality (FEPOS) cohort established between 2017 and 2019. Plasma samples from their mothers, primarily from the first trimester, were retrieved from the Danish National Biobank and levels of 15 PFAS were measured. Seven PFAS had detectable levels above the limit of detection in formula presented of the samples and were included in analyses. Semen quality, testicular volume, and levels of reproductive hormones and PFAS were assessed in the young men. We used weighted quantile sum (WQS) regression to estimate the associations between combined exposure to maternal PFAS and reproductive function, and negative binomial regression to estimate the associations of single substances, while adjusting for a range of a priori-defined fetal and postnatal risk factors. RESULTS: By a 1-unit increase in the WQS index, combined maternal PFAS exposure was associated with lower sperm concentration (formula presented ; 95% CI: formula presented ), total sperm count (formula presented ; 95% CI: formula presented ), and a higher proportion of nonprogressive and immotile sperm (5%; 95% CI: 1%, 8%) in the young men. Different PFAS contributed to the associations with varying strengths; however, perfluoroheptanoic acid was identified as the main contributor in the analyses of all three outcomes despite the low concentration. We saw no clear association between exposure to maternal PFAS and testicular volume or reproductive hormones. DISCUSSION: In a sample of young men from the general Danish population, we observed consistent inverse associations between exposure to maternal PFAS and semen quality. The study needs to be replicated in other populations, taking combined exposure, as well as emerging short-chain PFAS, into consideration. https://doi.org/10.1289/EHP10285.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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Hærvig, Katia Ke ...
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Petersen, Kajsa ...
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Hougaard, Karin ...
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Lindh, Christian
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Ramlau-Hansen, C ...
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Toft, Gunnar
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Giwercman, Aleks ...
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Høyer, Birgit Bj ...
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