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High CD34 surface e...
High CD34 surface expression in BCP-ALL predicts poor induction therapy response and is associated with altered expression of genes related to cell migration and adhesion
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- Modvig, Signe (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Wernersson, Rasmus (författare)
- Technical University of Denmark
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- Øbro, Nina Friesgaard (författare)
- Copenhagen University Hospital
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- Olsen, Lars Rønn (författare)
- Technical University of Denmark
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- Christensen, Claus (författare)
- Copenhagen University Hospital
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- Rosthøj, Susanne (författare)
- University of Copenhagen
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- Degn, Matilda (författare)
- Copenhagen University Hospital
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- Jürgensen, Gitte Wullf (författare)
- Copenhagen University Hospital
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- Madsen, Hans O. (författare)
- Copenhagen University Hospital
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- Albertsen, Birgitte Klug (författare)
- Aarhus University,Aarhus University Hospital
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- Wehner, Peder Skov (författare)
- Odense University Hospital
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- Rosthøj, Steen (författare)
- Aalborg University Hospital
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- Lilljebjörn, Henrik (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups
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- Fioretos, Thoas (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Schmiegelow, Kjeld (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Marquart, Hanne Vibeke (författare)
- Copenhagen University Hospital
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(creator_code:org_t)
- 2022-04-07
- 2022
- Engelska.
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Ingår i: Molecular Oncology. - : Wiley. - 1574-7891 .- 1878-0261. ; 16:10, s. 2015-2030
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Minimal residual disease (MRD) constitutes the most important prognostic factor in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Flow cytometry is widely used in MRD assessment, yet little is known regarding the effect of different immunophenotypic subsets on outcome. In this study of 200 BCP-ALL patients, we found that a CD34-positive, CD38 dim-positive, nTdT dim-positive immunophenotype on the leukemic blasts was associated with poor induction therapy response and predicted an MRD level at the end of induction therapy (EOI) of ≥ 0.001. CD34 expression was strongly and positively associated with EOI MRD, whereas CD34-negative patients had a low relapse risk. Further, CD34 expression increased from diagnosis to relapse. CD34 is a stemness-associated cell-surface molecule, possibly involved in cell adhesion/migration or survival. Accordingly, genes associated with stemness were overrepresented among the most upregulated genes in CD34-positive leukemias, and protein–protein interaction networks showed an overrepresentation of genes associated with cell migration, cell adhesion, and negative regulation of apoptosis. The present work is the first to demonstrate a CD34-negative immunophenotype as a good prognostic factor in ALL, whereas high CD34 expression is associated with poor therapy response and an altered gene expression profile reminiscent of migrating cancer stem-like cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- acute lymphoblastic leukemia
- CD34
- cell migration
- immunophenotype
- prognosis
- protein–protein interaction networks
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- art (ämneskategori)
- ref (ämneskategori)
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Modvig, Signe
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Wernersson, Rasm ...
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Øbro, Nina Fries ...
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Olsen, Lars Rønn
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Christensen, Cla ...
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Rosthøj, Susanne
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visa fler...
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Degn, Matilda
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Jürgensen, Gitte ...
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Madsen, Hans O.
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Albertsen, Birgi ...
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Wehner, Peder Sk ...
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Rosthøj, Steen
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Lilljebjörn, Hen ...
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Fioretos, Thoas
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Schmiegelow, Kje ...
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Marquart, Hanne ...
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