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The relationship be...
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Alcala, KarineInternational Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, 150 Cours Albert Thomas, Lyon, France
(författare)
The relationship between blood pressure and risk of renal cell carcinoma
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022
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Oxford University Press (OUP),2022
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:80fbe351-68e9-4763-9db1-1ce8d639695a
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https://lup.lub.lu.se/record/80fbe351-68e9-4763-9db1-1ce8d639695aURI
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https://doi.org/10.1093/ije/dyac042DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199018URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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BACKGROUND: The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail.METHODS: Our study involved two prospective cohorts: the European Prospective Investigation into Cancer and Nutrition study and UK Biobank, including >700 000 participants and 1692 incident RCC cases. Risk analyses were conducted using flexible parametric survival models for DBP and SBP both separately as well as with mutuality adjustment and then adjustment for extended risk factors. We also carried out univariable and multivariable Mendelian randomization (MR) analyses (DBP: ninstruments = 251, SBP: ninstruments = 213) to complement the analyses of measured DBP and SBP.RESULTS: In the univariable analysis, we observed clear positive associations with RCC risk for both diastolic and SBP when measured ≥5 years before diagnosis and suggestive evidence for a stronger risk association in the year leading up to diagnosis. In mutually adjusted analysis, the long-term risk association of DBP remained, with a hazard ratio (HR) per standard deviation increment 10 years before diagnosis (HR10y) of 1.20 (95% CI: 1.10-1.30), whereas the association of SBP was attenuated (HR10y: 1.00, 95% CI: 0.91-1.10). In the complementary multivariable MR analysis, we observed an odds ratio for a 1-SD increment (ORsd) of 1.34 (95% CI: 1.08-1.67) for genetically predicted DBP and 0.70 (95% CI: 0.56-0.88) for genetically predicted SBP.CONCLUSION: The results of this observational and MR study are consistent with an important role of DBP in RCC aetiology. The relation between SBP and RCC risk was less clear but does not appear to be independent of DBP.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mariosa, DanielaInternational Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, 150 Cours Albert Thomas, Lyon, France
(författare)
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Smith-Byrne, KarlOxford University Hospital,Cancer Epidemiology Unit, Oxford Population Health, University of Oxford, Oxford, United Kingdom
(författare)
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Nasrollahzadeh Nesheli, DariushInternational Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, 150 Cours Albert Thomas, Lyon, France
(författare)
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Carreras-Torres, RobertGirona Biomedical Research Institute (IDIBGI),Group of Digestive Diseases and Microbiota, Institut d'Investigació Biomèdica de Girona-IDIBGI, Salt, Spain
(författare)
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Ardanaz Aicua, EvaNavarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain
(författare)
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Bondonno, Nicola PDanish Cancer Society Research Center, Copenhagen, Denmark; School of Biomedical Sciences, University of Western Australia, Royal Perth Hospital, Perth, Australia; Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
(författare)
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Bonet, CatalinaCatalan Institute of Oncology-Girona,Unit of Nutrition and Cancer, Catalan Institute of Oncology, ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute-(IDIBELL), l'Hospitalet de Llobregat, Barcelona, Spain
(författare)
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Brunström, MattiasUmeå universitet,Umeå University,Avdelningen för medicin(Swepub:umu)mabr0041
(författare)
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Bueno-de-Mesquita, BasCentre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
(författare)
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Chirlaque, María-DoloresCIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain
(författare)
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Christakoudi, SofiaDepartment of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, St Mary's Campus, London, United Kingdom; MRC Centre for Transplantation, King's College London, London, United Kingdom
(författare)
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Heath, Alicia KDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
(författare)
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Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Katzke, VerenaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Krogh, VittorioEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori di Milano, Milan, Italy
(författare)
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Ljungberg, Börje,Professor,1949-Umeå universitet,Umeå University,Urologi och andrologi(Swepub:umu)bolj0001
(författare)
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Martin, Richard MPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
(författare)
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May, AnneJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
(författare)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Department of Emergency and Internal Medicine, Skåne University Hospital, Malmö, Sweden(Swepub:lu)endo-ome
(författare)
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Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
(författare)
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Rodriguez-Barranco, MiguelAndalusian School Of Public Health (EASP),Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria Ibs. GRANADA, Granada, Spain; Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica, Madrid, Spain
(författare)
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Sacerdote, CarlottaUnit of Cancer Epidemiology, Cittàdella Salute e della Scienza University-Hospital, Turin, Italy
(författare)
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Stocks, TanjaLund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Registerbaserad epidemiologi - Stocks,Institutionen för translationell medicin,Register-based epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Translational Medicine,Department of Clinical Sciences Lund, Lund University, Lund, Sweden(Swepub:lu)med-tss
(författare)
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Tjønneland, AnneDanish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
(författare)
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Travis, Ruth COxford University Hospital,Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
(författare)
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Vermeulen, RoelInstitute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands
(författare)
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Chanock, StephenNational Cancer Institute, Lithuania,Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
(författare)
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Purdue, MarkNational Cancer Institute, Lithuania,Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
(författare)
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Weiderpass, ElisabeteInternational Agency for Research on Cancer (IARC/WHO), Lyon, France
(författare)
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Muller, DavidImperial College London, London, United Kingdom
(författare)
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Brennan, PaulInternational Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, 150 Cours Albert Thomas, Lyon, France
(författare)
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Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, 150 Cours Albert Thomas, Lyon, France
(författare)
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International Agency for Research on Cancer, World Health OrganizationInternational Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, 150 Cours Albert Thomas, Lyon, France
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Epidemiology: Oxford University Press (OUP)51:4, s. 1317-13271464-36850300-5771
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Alcala, Karine
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Mariosa, Daniela
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Smith-Byrne, Kar ...
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Nasrollahzadeh N ...
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Carreras-Torres, ...
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Ardanaz Aicua, E ...
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visa fler...
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Bondonno, Nicola ...
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Bonet, Catalina
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Brunström, Matti ...
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Bueno-de-Mesquit ...
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Chirlaque, María ...
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Christakoudi, So ...
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Heath, Alicia K
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Kaaks, Rudolf
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Katzke, Verena
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Krogh, Vittorio
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Ljungberg, Börje ...
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Martin, Richard ...
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May, Anne
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Melander, Olle
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Palli, Domenico
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Rodriguez-Barran ...
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Sacerdote, Carlo ...
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Stocks, Tanja
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Tjønneland, Anne
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Travis, Ruth C
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Vermeulen, Roel
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Chanock, Stephen
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Purdue, Mark
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Weiderpass, Elis ...
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Muller, David
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Brennan, Paul
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Johansson, Matti ...
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