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Search: WFRF:(Gomez Cristina) > (2015-2019) > TRPA1-FGFR2 binding...

  • Berrout, JonathanUniversity of Leeds (author)

TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-10-16
  • Springer Science and Business Media LLC,2017

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:81021cf5-a69b-40d6-94d6-6cfda6ae0972
  • https://lup.lub.lu.se/record/81021cf5-a69b-40d6-94d6-6cfda6ae0972URI
  • https://doi.org/10.1038/s41467-017-00983-wDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD), where its role and mechanism of action remain unknown. We have previously established that the membrane receptor FGFR2 drives LUAD progression through aberrant protein-protein interactions mediated via its C-terminal proline-rich motif. Here we report that the N-terminal ankyrin repeats of TRPA1 directly bind to the C-terminal proline-rich motif of FGFR2 inducing the constitutive activation of the receptor, thereby prompting LUAD progression and metastasis. Furthermore, we show that upon metastasis to the brain, TRPA1 gets depleted, an effect triggered by the transfer of TRPA1-targeting exosomal microRNA (miRNA-142-3p) from brain astrocytes to cancer cells. This downregulation, in turn, inhibits TRPA1-mediated activation of FGFR2, hindering the metastatic process. Our study reveals a direct binding event and characterizes the role of TRPA1 ankyrin repeats in regulating FGFR2-driven oncogenic process; a mechanism that is hindered by miRNA-142-3p.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kyriakopoulou, EleniUniversity of Leeds (author)
  • Moparthi, LavanyaLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)bioc-lmi (author)
  • Hogea, Alexandra S.University of Leeds (author)
  • Berrout, LizaUniversity of Texas (author)
  • Ivan, Cristina-ElenaUniversity of Texas (author)
  • Lorger, MihaelaSt James's University Hospital (author)
  • Boyle, John F.University of Leeds (author)
  • Peers, ChrisUniversity of Leeds (author)
  • Muench, StephenUniversity of Leeds (author)
  • Gomez, Jacobo EliesUniversity of Leeds (author)
  • Hu, XinUniversity of Texas (author)
  • Hurst, CarolynUniversity of Leeds (author)
  • Hall, ThomasUniversity of Leeds (author)
  • Umamaheswaran, SujanithaAnna University (author)
  • Wesley, LauraUniversity of Leeds (author)
  • Gagea, MihaiUniversity of Texas (author)
  • Shires, MichaelSt James's University Hospital (author)
  • Manfield, IainUniversity of Leeds (author)
  • Knowles, Margaret A.University of Leeds (author)
  • Davies, SimonUniversity of Leeds (author)
  • Suhling, KlausKing's College London (author)
  • Gonzalez, Yurema TeijeiroKing's College London (author)
  • Carragher, NeilUniversity of Edinburgh (author)
  • Macleod, Kenneth G.University of Edinburgh (author)
  • Abbott, N JoanKing's College London (author)
  • Calin, George AUniversity of Texas (author)
  • Gamper, NikitaUniversity of Leeds (author)
  • Zygmunt, Peter M.Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kfar-pzy (author)
  • Timsah, ZahraUniversity of Leeds (author)
  • University of LeedsAvdelningen för klinisk kemi och farmakologi (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC8:12041-1723

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