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TRPA1-FGFR2 binding...
TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
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- Berrout, Jonathan (author)
- University of Leeds
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- Kyriakopoulou, Eleni (author)
- University of Leeds
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- Moparthi, Lavanya (author)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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- Hogea, Alexandra S. (author)
- University of Leeds
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- Berrout, Liza (author)
- University of Texas
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- Ivan, Cristina-Elena (author)
- University of Texas
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- Lorger, Mihaela (author)
- St James's University Hospital
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- Boyle, John F. (author)
- University of Leeds
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- Peers, Chris (author)
- University of Leeds
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- Muench, Stephen (author)
- University of Leeds
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- Gomez, Jacobo Elies (author)
- University of Leeds
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- Hu, Xin (author)
- University of Texas
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- Hurst, Carolyn (author)
- University of Leeds
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- Hall, Thomas (author)
- University of Leeds
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- Umamaheswaran, Sujanitha (author)
- Anna University
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- Wesley, Laura (author)
- University of Leeds
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- Gagea, Mihai (author)
- University of Texas
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- Shires, Michael (author)
- St James's University Hospital
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- Manfield, Iain (author)
- University of Leeds
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- Knowles, Margaret A. (author)
- University of Leeds
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- Davies, Simon (author)
- University of Leeds
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- Suhling, Klaus (author)
- King's College London
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- Gonzalez, Yurema Teijeiro (author)
- King's College London
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- Carragher, Neil (author)
- University of Edinburgh
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- Macleod, Kenneth G. (author)
- University of Edinburgh
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- Abbott, N Joan (author)
- King's College London
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- Calin, George A (author)
- University of Texas
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- Gamper, Nikita (author)
- University of Leeds
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- Zygmunt, Peter M. (author)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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- Timsah, Zahra (author)
- University of Leeds
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(creator_code:org_t)
- 2017-10-16
- 2017
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD), where its role and mechanism of action remain unknown. We have previously established that the membrane receptor FGFR2 drives LUAD progression through aberrant protein-protein interactions mediated via its C-terminal proline-rich motif. Here we report that the N-terminal ankyrin repeats of TRPA1 directly bind to the C-terminal proline-rich motif of FGFR2 inducing the constitutive activation of the receptor, thereby prompting LUAD progression and metastasis. Furthermore, we show that upon metastasis to the brain, TRPA1 gets depleted, an effect triggered by the transfer of TRPA1-targeting exosomal microRNA (miRNA-142-3p) from brain astrocytes to cancer cells. This downregulation, in turn, inhibits TRPA1-mediated activation of FGFR2, hindering the metastatic process. Our study reveals a direct binding event and characterizes the role of TRPA1 ankyrin repeats in regulating FGFR2-driven oncogenic process; a mechanism that is hindered by miRNA-142-3p.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Berrout, Jonatha ...
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Kyriakopoulou, E ...
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Moparthi, Lavany ...
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Hogea, Alexandra ...
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Berrout, Liza
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Ivan, Cristina-E ...
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show more...
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Lorger, Mihaela
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Boyle, John F.
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Peers, Chris
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Muench, Stephen
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Gomez, Jacobo El ...
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Hu, Xin
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Hurst, Carolyn
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Hall, Thomas
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Umamaheswaran, S ...
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Wesley, Laura
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Gagea, Mihai
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Shires, Michael
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Manfield, Iain
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Knowles, Margare ...
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Davies, Simon
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Suhling, Klaus
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Gonzalez, Yurema ...
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Carragher, Neil
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Macleod, Kenneth ...
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Abbott, N Joan
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Calin, George A
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Gamper, Nikita
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Zygmunt, Peter M ...
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Timsah, Zahra
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University