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Endoscopic and Surg...
Endoscopic and Surgical Management of Non-Metastatic Ampullary Neuroendocrine Neoplasia : A Multi-Institutional Pancreas2000/EPC Study
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- Karam, Elias (författare)
- University Of Tours
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- Hollenbach, Marcus (författare)
- Leipzig University
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- Abou Ali, Einas (författare)
- Cochin Hospital
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- Auriemma, Francesco (författare)
- Humanitas Research Hospital
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- Anderloni, Andrea (författare)
- Policlinico San Matteo Pavia Fondazione
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- Barbier, Louise (författare)
- University Of Tours
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- Belfiori, Giulio (författare)
- Vita-Salute San Raffaele University
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- Caillol, Fabrice (författare)
- Institut Paoli-Calmettes
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- Crippa, Stefano (författare)
- Vita-Salute San Raffaele University
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- Del Chiaro, Marco (författare)
- University of Colorado School of Medicine
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- De Ponthaud, Charles (författare)
- Pitié-Salpêtrière University Hospital
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- Dahel, Yanis (författare)
- Institut Paoli-Calmettes
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- Falconi, Massimo (författare)
- Vita-Salute San Raffaele University
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- Giovannini, Marc (författare)
- Institut Paoli-Calmettes
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- Heling, Dominik (författare)
- University Hospital Bonn
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- Inoue, Yosuke (författare)
- Cancer Institute Hospital of Japanese Foundation for Cancer Research
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- Jarnagin, William R. (författare)
- Memorial Sloan-Kettering Cancer Center
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- Leung, Galen (författare)
- University of Pennsylvania
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Lupinacci, Renato M. (författare)
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- Mariani, Alberto (författare)
- Vita-Salute San Raffaele University
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Masaryk, Viliam (författare)
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- Miksch, Rainer Christoph (författare)
- Ludwig-Maximilian University of Munich
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Musquer, Nicolas (författare)
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Napoleon, Bertrand (författare)
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- Oba, Atsushi (författare)
- University of Colorado School of Medicine
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- Partelli, Stefano (författare)
- Vita-Salute San Raffaele University
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- Petrone, Maria C. (författare)
- Vita-Salute San Raffaele University
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- Prat, Frédéric (författare)
- Cochin Hospital
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- Repici, Alessandro (författare)
- Humanitas Research Hospital
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- Sauvanet, Alain (författare)
- Beaujon Hospital
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- Salzmann, Katrin (författare)
- University Medical Center Göttingen
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- Schattner, Mark A. (författare)
- Memorial Sloan-Kettering Cancer Center
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- Schulick, Richard (författare)
- University of Colorado School of Medicine
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- Schwarz, Lilian (författare)
- Hopital Charles Nicolle
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- Soares, Kevin (författare)
- Memorial Sloan-Kettering Cancer Center
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- Souche, François R. (författare)
- Montpellier University Hospital
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- Truant, Stéphanie (författare)
- Lille University Hospital
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- Vaillant, Jean C. (författare)
- Pitié-Salpêtrière University Hospital
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- Wang, Tiegong (författare)
- Memorial Sloan-Kettering Cancer Center,Cangzhou Central Hospital
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- Wedi, Edris (författare)
- University Medical Center Göttingen,Sana Hospital Lichtenberg
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- Werner, Jens (författare)
- Ludwig-Maximilian University of Munich
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- Weismüller, Tobias J. (författare)
- Vivantes Humboldt Hospital,Pitié-Salpêtrière University Hospital
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- Wichmann, Dörte (författare)
- University Hospital of Tubingen
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- Will, Uwe (författare)
- SRH Wald-Klinikum Gera
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- Zaccari, Piera (författare)
- Vita-Salute San Raffaele University
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- Gulla, Aiste (författare)
- Vilnius University,MedStar Georgetown University Hospital
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- Heise, Christian (författare)
- Martin-Luther-Universität Halle-Wittenberg
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- Regner, Sara (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Gaujoux, Sébastien (författare)
- Paris-Sorbonne University,Pitié-Salpêtrière University Hospital
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(creator_code:org_t)
- 2023
- 2023
- Engelska 11 s.
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Ingår i: Neuroendocrinology. - 0028-3835. ; 113:10, s. 1024-1034
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Ampullary neuroendocrine neoplasia (NEN) is rare and evidence regarding their management is scarce. This study aimed to describe clinicopathological features, management, and prognosis of ampullary NEN according to their endoscopic or surgical management. Methods: From a multi-institutional international database, patients treated with either endoscopic papillectomy (EP), transduodenal surgical ampullectomy (TSA), or pancreaticoduodenectomy (PD) for ampullary NEN were included. Clinical features, post-procedure complications, and recurrences were assessed. Results: 65 patients were included, 20 (30.8%) treated with EP, 19 (29.2%) with TSA, and 26 (40%) with PD. Patients were mostly asymptomatic (n = 46; 70.8%). Median tumor size was 17 mm (12-22), tumors were mostly grade 1 (70.8%) and pT2 (55.4%). Two (10%) EP resulted in severe American Society for Gastrointestinal Enterology (ASGE) adverse post-procedure complications and 10 (50%) were R0. Clavien 3-5 complications did not occur after TSA and in 4, including 1 postoperative death (15.4%) of patients after PD, with 17 (89.5%) and 26 R0 resection (100%), respectively. The pN1/2 rate was 51.9% (n = 14) after PD. Tumor size larger than 1 cm (i.e., pT stage >1) was a predictor for R1 resection (p < 0.001). Three-year overall survival and disease-free survival after EP, TSA, and PD were 92%, 68%, 92% and 92%, 85%, 73%, respectively. Conclusion: Management of ampullary NEN is challenging. EP should not be performed in lesions larger than 1 cm or with a endoscopic ultrasonography T stage beyond T1. Local resection by TSA seems safe and feasible for lesions without nodal involvement. PD should be preferred for larger ampullary NEN at risk of nodal metastasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Ampulla of vater
- Ampullary neuroendocrine neoplasia
- Endoscopic papillectomy
- Pancreaticoduodenectomy
- Transduodenal surgical ampullectomy
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Karam, Elias
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Hollenbach, Marc ...
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Abou Ali, Einas
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Auriemma, France ...
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Anderloni, Andre ...
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Barbier, Louise
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Belfiori, Giulio
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Caillol, Fabrice
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Crippa, Stefano
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Del Chiaro, Marc ...
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De Ponthaud, Cha ...
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Dahel, Yanis
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Falconi, Massimo
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Giovannini, Marc
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Heling, Dominik
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Inoue, Yosuke
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Jarnagin, Willia ...
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Leung, Galen
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Lupinacci, Renat ...
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Mariani, Alberto
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Masaryk, Viliam
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Miksch, Rainer C ...
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Musquer, Nicolas
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Napoleon, Bertra ...
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Oba, Atsushi
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Partelli, Stefan ...
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Petrone, Maria C ...
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Prat, Frédéric
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Repici, Alessand ...
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Sauvanet, Alain
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Salzmann, Katrin
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Schattner, Mark ...
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Schulick, Richar ...
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Schwarz, Lilian
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Soares, Kevin
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Souche, François ...
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Truant, Stéphani ...
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Vaillant, Jean C ...
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Wang, Tiegong
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Wedi, Edris
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Werner, Jens
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Weismüller, Tobi ...
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Wichmann, Dörte
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Will, Uwe
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Zaccari, Piera
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Gulla, Aiste
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Heise, Christian
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Regner, Sara
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Gaujoux, Sébasti ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Neuroendocrinolo ...
- Av lärosätet
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Lunds universitet