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Effects of compound...
Effects of compounds from physalis angulata on fatty acid synthesis and glucose metabolism in HEPG2 cells via the AMP-activated protein kinase pathway
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- Hoa, Hoang Thai (författare)
- National Institute of Medicinal Materials, Vietnam
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- Thu, Nguyen Thi (författare)
- National Institute of Medicinal Materials, Vietnam
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- Dong, Nguyen Thuong (författare)
- National Institute of Medicinal Materials, Vietnam
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- Oanh, Tran Thi (författare)
- iON - Institute of Research and Development of Organic Products Vietnam
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- Hien, Tran Thi (författare)
- Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Cancerinfektion,Forskargrupper vid Lunds universitet,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine,Cancer Infection,Lund University Research Groups,Thai Binh University of Medicine and Pharmacy
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- Ha, Do Thi (författare)
- National Institute of Medicinal Materials, Vietnam
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(creator_code:org_t)
- 2020
- 2020
- Engelska 7 s.
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Ingår i: Natural Product Sciences. - 1226-3907. ; 26:3, s. 200-206
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- The ability of the total extract from Physalis angulata; three fractions after partitioning with n-hexane, ethyl acetate (TBE), and water; and four withanolides (compounds 1 – 4) to phosphorylate 5'-adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in HepG2 cells was evaluated. The TBE fraction (50 μg/mL) activated p-ACC and p-AMPK expression most strongly. Compounds 1 – 4 (10 μM) upregulated p-ACC expression at different levels. Compound 4 induced the most significant changes in p-AMPK expression, followed by 1 and 2. Sterol regulatory element-binding proteins (SREBPs) play a functional role in the transcriptional regulation of the lipogenic pathway, including fatty acid synthase (FAS) and ACC. The effects of compounds 2 and 4 (10 μM) on FAS and SREBP-1c expression under high glucose conditions (30 mM) in HepG2 cells were evaluated further. Both dose-dependently inhibited FAS and SREBP-1c expression as well as lipid accumulation (1 – 10 μM) were compared to high-concentration glucose control, which upregulated FAS and SREBP-1c. These results suggest that compounds 2 and 4 upregulate AMPK, suppress FAS and SREBP-1c, and have potential effects on glucose and lipid metabolism.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- ACC
- AMPK
- FAS
- Physalis angulata
- SREBP-1c
- Withanolides
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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