Sökning: WFRF:(Engström Henrik) >
Subclinical atheros...
Subclinical atherosclerosis in patients with cyanotic congenital heart disease
-
- Tarp, Julie Bjerre (författare)
- University of Copenhagen
-
- Sørgaard, Mathias Holm (författare)
- University of Copenhagen
-
- Christoffersen, Christina (författare)
- University of Copenhagen,Copenhagen University Hospital
-
visa fler...
-
- Jensen, Annette Schophuus (författare)
- University of Copenhagen
-
- Sillesen, Henrik (författare)
- University of Copenhagen
-
- Celermajer, David (författare)
- Royal Prince Alfred Hospital
-
- Eriksson, Peter J, 1959 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
- Estensen, Mette Elise (författare)
- Norwegian Radium Hospital
-
- Nagy, Edit (författare)
- Karolinska Institutet,Karolinska University Hospital
-
- Holstein-Rathlou, Niels Henrik (författare)
- University of Copenhagen
-
- Engstrøm, Thomas (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Copenhagen
-
- Søndergaard, Lars (författare)
- University of Copenhagen
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
-
Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 277, s. 97-103
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://gup.ub.gu.se...
-
visa färre...
Abstract
Ämnesord
Stäng
- Introduction: Survival in patients with cyanotic congenital heart disease (CCHD) has improved dramatically. The result is an ageing population with risk of acquired heart disease. Previous small uncontrolled studies suggested that these patients are protected against the development of atherosclerosis. To test this hypothesis, we sought to determine the prevalence of subclinical atherosclerosis in a larger population of patients with CCHD. Method: We compared the prevalence of subclinical atherosclerosis in adult CCHD patients from Denmark, Sweden, Norway and Australia, with that in age-, sex-, smoking status-, and body mass index matched controls. Coronary artery atherosclerosis was assessed on computed tomography with coronary artery calcification (CAC) score. Subclinical atherosclerosis was defined by CAC-score > 0. Carotid artery atherosclerosis was evaluated using ultrasound by measuring carotid plaque thickness (cPT-max) and carotid intima media thickness (CIMT). Lipid status was evaluated as an important atherosclerotic risk factor. Results: Seventy-four patients with CCHD (57% women, median age 49.5 years) and 74 matched controls (57% women, median age 50.0 years) were included. There were no differences between the groups in: CAC-score > 0 (21% vs. 19%, respectively; p = 0.8), carotid plaques (19% vs. 9%, respectively; p = 0.1), cPT-max (2.3 mm vs. 2.8 mm, respectively; p = 0.1) or CIMT (0.61 mm vs. 0.61 mm, respectively; p = 0.98). And further no significant differences in lipoprotein concentrations measured by ultracentrifugation. Conclusion: Young adults with CCHD have similar cardiovascular risk factor profiles and measures of subclinical atherosclerosis, compared with controls. Given their increasing life expectancies, athero-preventive strategies should be an important part of their clinical management.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Cardiovascular disease
- Carotid artery atherosclerosis
- Coronary artery atherosclerosis
- Coronary artery calcification
- Cyanotic congenital heart disease
- Hyperlipidemia
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Tarp, Julie Bjer ...
-
Sørgaard, Mathia ...
-
Christoffersen, ...
-
Jensen, Annette ...
-
Sillesen, Henrik
-
Celermajer, Davi ...
-
visa fler...
-
Eriksson, Peter ...
-
Estensen, Mette ...
-
Nagy, Edit
-
Holstein-Rathlou ...
-
Engstrøm, Thomas
-
Søndergaard, Lar ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Lunds universitet
-
Karolinska Institutet
-
Göteborgs universitet