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High incidence of c...
High incidence of chronic graft-versus-host disease after myeloablative allogeneic stem cell transplantation for chronic lymphocytic leukemia in Sweden : graft-versus-leukemia effect protects against relapse
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- Machaczka, Maciej (author)
- Karolinska Institutet,Division of Hematology, Department of Medicine at Huddinge, Karolinska Institutet, Stockholm, Sweden; Hematology Center Karolinska, Karolinska University Hospital, Huddinge M54, 141 86 Stockholm, Sweden
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- Johansson, Jan-Erik (author)
- Department of Hematology and Coagulation, Sahlgrenska University Hospital, Göteborg, Sweden
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- Remberger, Mats (author)
- Karolinska Institutet,Division of Clinical Immunology and Transfusion Medicine, Karolinska Institute, Stockholm, Sweden
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- Hallböök, Helene (author)
- Karolinska Institutet,Uppsala universitet,Hematologi,Department of Hematology, Uppsala University Hospital, Uppsala, Sweden
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- Lazarevic, Vladimir Lj (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Department of Hematology, Skåne University Hospital, Lund University, Lund, Sweden
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- Wahlin, Björn Engelbrekt (author)
- Karolinska Institutet,Division of Hematology, Department of Medicine at Huddinge, Karolinska Institutet, Stockholm, Sweden; Hematology Center Karolinska, Karolinska University Hospital, Huddinge M54, 141 86 Stockholm, Sweden
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- Omar, Hamdy (author)
- Karolinska Institutet,Division of Hematology, Department of Medicine at Huddinge, Karolinska Institutet, Stockholm, Sweden; Hematology Center Karolinska, Karolinska University Hospital, Huddinge M54, 141 86 Stockholm, Sweden
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- Wåhlin, Anders (author)
- Umeå universitet,Umeå University,Institutionen för strålningsvetenskaper
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Department of Hematology, Skåne University Hospital, Lund University, Lund, Sweden
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- Kimby, Eva (author)
- Karolinska Institutet,Division of Hematology, Department of Medicine at Huddinge, Karolinska Institutet, Stockholm, Sweden; Hematology Center Karolinska, Karolinska University Hospital, Huddinge M54, 141 86 Stockholm, Sweden
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- Hägglund, Hans (author)
- Uppsala universitet,Karolinska Institutet,Hematologi,Division of Hematology, Department of Medicine at Huddinge, Karolinska Institutet, Stockholm, Sweden; Hematology Center Karolinska, Karolinska University Hospital, Huddinge M54, 141 86 Stockholm, Sweden
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(creator_code:org_t)
- 2013-11-09
- 2013
- English.
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In: Medical Oncology. - : Springer Science and Business Media LLC. - 1559-131X .- 1357-0560. ; 30:4, s. 762-762
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a potentially curative treatment option for eligible patients with chronic lymphocytic leukemia (CLL). However, it is known that cure of CLL is only possible if a graft-versus-leukemia effect is present. Between 1994 and 2007, 48 adults underwent allo-SCT for poor-risk CLL in Sweden. Of these, ten (21%) patients aged 24-53 years (median: 46 years) received myeloablative conditioning (MAC), based on TBI and cyclophosphamide. All MAC patients had refractory, poorly controlled CLL before allo-SCT (partial remission in 9/10 patients and progressive disease in one). The cumulative incidence of acute graft-versus-host disease (GVHD) grades II-IV was 30%. Nine patients developed chronic GVHD; extensive in four. Rates of nonrelapse mortality at 1, 3 and 10 years were 0, 10 and 20%, respectively. Two patients relapsed 36 and 53 months after transplantation. Six patients were still alive after a median follow-up time of 11.5 years (range 5.9-13.7). The probabilities of relapse-free and overall survival from 1, 3 and 5 years after transplantation were 100, 90 and 70%, and 100, 90 and 80%, respectively. Nevertheless, our analysis of long-term outcome after MAC allo-SCT for CLL suggests that younger patients with poorly controlled CLL may benefit from MAC allo-SCT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adult
- Disease Progression
- Female
- Graft vs Host Disease
- Graft vs Leukemia Effect
- Hematopoietic Stem Cell Transplantation
- Humans
- Kaplan-Meier Estimate
- Leukemia, Lymphocytic, Chronic, B-Cell
- Male
- Middle Aged
- Sweden
- Transplantation, Homologous
- Young Adult
- Allogeneic stem cell transplantation
Publication and Content Type
- art (subject category)
- ref (subject category)
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Machaczka, Macie ...
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Johansson, Jan-E ...
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Remberger, Mats
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Hallböök, Helene
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Lazarevic, Vladi ...
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Wahlin, Björn En ...
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Omar, Hamdy
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Wåhlin, Anders
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Juliusson, Gunna ...
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Kimby, Eva
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Hägglund, Hans
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Medical Oncology
- By the university
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Lund University
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Uppsala University
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Umeå University
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Karolinska Institutet