Twins studies as a model for studies on the interaction between smoking and genetic factors in the development of chronic bronchitis

Smoking is the main risk factor for COPD (chronic obstructive pulmonary disease) but genetic factors are of importance, since only a subset of smokers develops the disease. Sex differences have been suggested both in disease prevalence and response to environmental exposures. Furthermore, it has been shown that acquisition of 'addiction' to smoking is partly genetically mediated. Disease cases and smoking habits were identified in 44919 twins aged > 40 years from the Swedish Twin Registry. Disease was defined as self-reported chronic bronchitis or emphysema, or recurrent cough with phlegm. The results showed that chronic bronchitis seems to be more prevalent among females, and that the heritability estimate for chronic bronchitis was a moderate 40% and only 14% of the genetic influences were shared by smoking. In addition, 392 twins have been invited to a clinical investigation to evaluate: (i) to what extent genetic factors contribute to individual differences (variation) in FEV1 (forced expiratory volume in 1 s), vital capacity and l (diffusion capacity), taking sex into consideration, and (ii) whether smoking behaviour and respiratory symptoms influence these estimates.

NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
inflammatory marker
chronic obstructive pulmonary disease (COPD)
heritability
multi-slice computed tomography (MSCT)
smoking
twin

Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (author)
Anderson, MartinKarolinska Institutet (author)
Hallberg, JennyKarolinska Institutet (author)
Edula, Goutham (author)
de Verdier, Maria Gerhardsson (author)
Dahlback, Magnus (author)
Lindberg, Claes M. (author)
Forsman-Semb, Kristina (author)
Nihlén, UlfLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)lung-uni (author)
Fehniger, Thomas E. (author)
Karolinska InstitutetKardiovaskulär forskning - epidemiologi (creator_code:org_t)

By the author/editor: Svartengren, Mag ...; Engström, Gunnar; Anderson, Martin; Hallberg, Jenny; Edula, Goutham; de Verdier, Mari ...; show more...; Dahlback, Magnus; Lindberg, Claes ...; Forsman-Semb, Kr ...; Nihlén, Ulf; Fehniger, Thomas ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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