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Late mortality afte...
Late mortality after autologous blood or marrow transplantation in childhood : A Blood or Marrow Transplant Survivor Study-2 report
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- Holmqvist, Anna Sällfors (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Chen, Yanjun (författare)
- University of Alabama
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- Wu, Jessica (författare)
- University of Alabama
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- Battles, Kevin (författare)
- University of Alabama
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- Bhatia, Ravi (författare)
- University of Alabama
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- Francisco, Liton (författare)
- University of Alabama
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- Hageman, Lindsey (författare)
- University of Alabama
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- Kung, Michelle (författare)
- University of Alabama
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- Ness, Emily (författare)
- University of Alabama
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- Parman, Mariel (författare)
- University of Alabama
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- Salzman, Donna (författare)
- University of Alabama
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- Winther, Jeanette Falck (författare)
- Aarhus University,Danish Cancer Society
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- Rosenthal, Joseph (författare)
- City of Hope National Medical Center
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- Forman, Stephen J. (författare)
- City of Hope National Medical Center
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- Weisdorf, Daniel J. (författare)
- University of Minnesota
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- Arora, Mukta (författare)
- University of Minnesota
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- Armenian, Saro H. (författare)
- City of Hope National Medical Center
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- Bhatia, Smita (författare)
- University of Alabama
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(creator_code:org_t)
- American Society of Hematology, 2018
- 2018
- Engelska 10 s.
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 131:24, s. 2720-2729
- Relaterad länk:
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http://dx.doi.org/10...
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https://ashpublicati...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Autologous blood or marrow transplantation (BMT) is a curative option for several types of childhood cancer. However, there is little information regarding the risk of late mortality. We examined all-cause mortality, relapse-related mortality (RRM), and nonrelapse-related mortality (NRM) in 2-year survivors of autologous BMT performed before age 22 between 1980 and 2010 at 1 of 2 US transplant centers. Vital status information was collected using medical records, National Death Index, and Accurint databases. Overall survival was calculated using Kaplan-Meier techniques. Cumulative incidence of mortality used competing risk methods. Standardized mortality ratio (SMR) was calculated using age-, sex-, and calendar-specific mortality rates from Centers for Disease Control and Prevention. Cox regression analysis was used to determine predictors of all-cause late mortality. Among the 345 2-year survivors, 103 deaths were observed, yielding an overall survival of 70.3% 15 years post-BMT. The leading causes of death included primary disease (50.0%), subsequent neoplasm (21.4%), and infection (18.2%). Overall, the cohort was at a 22-fold increased risk of late mortality (SMR, 21.8; 95% CI, 17.9-26.3), compared with the general population. Mortality rates remained elevated among the 10-year survivors (SMR, 20.6; 95% CI, 9.9-37.2) but approached those of the general population ≥15 years post-BMT. The 10-year cumulative incidence of RRM (14.3%) exceeded that of NRM (10.4%). The 10-year cumulative mortality rate declined over time (<1990, 35.1%; 1990-1999, 25.6%; 2000-2010, 21.8%; P 5 .05). In conclusion, childhood autologous BMT recipients have an increased risk of late mortality, compared with the general population. The late mortality rates have declined over the past 3 decades.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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Holmqvist, Anna ...
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Chen, Yanjun
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Wu, Jessica
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Battles, Kevin
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Bhatia, Ravi
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Francisco, Liton
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visa fler...
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Hageman, Lindsey
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Kung, Michelle
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Ness, Emily
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Parman, Mariel
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Salzman, Donna
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Winther, Jeanett ...
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Rosenthal, Josep ...
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Forman, Stephen ...
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Weisdorf, Daniel ...
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Arora, Mukta
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Armenian, Saro H ...
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Bhatia, Smita
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