Association between tumor tissue TIMP-1 levels and objective response to first-line chemotherapy in metastatic breast cancer.

Klintman, MarieLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine (author)

In a previous study from our laboratory, high tumor levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) have been associated with an adverse response to chemotherapy in metastatic breast cancer suggesting that TIMP-1, which is known to inhibit apoptosis, may be a new predictive marker in this disease. The purpose of this study was to investigate the association between TIMP-1 and objective response to chemotherapy in an independent patient population consisting of patients with metastatic breast cancer from Sweden and Denmark. TIMP-1 was measured using ELISA in 162 primary tumor extracts from patients who later developed metastatic breast cancer and these levels were related to the objective response to first-line chemotherapy. Increasing levels of TIMP-1 were associated with a decreasing probability of response to treatment, reaching borderline significance (OR = 1.59, 95% CI: 0.97-2.62, P = 0.07). This OR is very similar to the result from our previous study. Increasing levels of TIMP-1 were also associated with a shorter disease-free survival and overall survival, however, not statistically significant. The results from the present study support previous data that TIMP-1 is associated with objective response to chemotherapy for metastatic breast cancer.

Ornbjerg Würtz, Sidse (author)
Christensen, Ib (author)
Bræmer Hertel, Pernille (author)
Fernö, MårtenLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-mfe (author)
Malmberg, Martin (author)
Mouridsen, Henning (author)
Cold, Frederik (author)
Schrohl, Anne-Sofie (author)
Foekens, John (author)
Malmström, PerLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-pma (author)
Brünner, Nils (author)
Bröstcancer-genetikSektion I (creator_code:org_t)

In:Breast Cancer Research and Treatment: Springer Science and Business Media LLC121, s. 365-3711573-72170167-6806

By the author/editor: Klintman, Marie; Ornbjerg Würtz, ...; Christensen, Ib; Bræmer Hertel, P ...; Fernö, Mårten; Malmberg, Martin; show more...; Mouridsen, Henni ...; Cold, Frederik; Schrohl, Anne-So ...; Foekens, John; Malmström, Per; Brünner, Nils; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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