Online monitoring of urea concentration in dialysate with dual-beam Fourier-transform near-infrared spectroscopy

• The robustness of a dual-beam, optical null, Fourier-transform near-infrared (FTNIR) spectrometer was investigated by means of online, near-infrared measurements and predictions of urea concentrations in spent dialysate during hemodialysis treatment. Simple multivariate calibration using a few factors based on a small number of prepared samples provided stable and accurate predictions over a period of 1 month. The calibration was robust when faced with adjustment of reference cell intensity and did not require a daily measured reference spectrum. The root-mean-square error of prediction of urea was 0.4 mM based on a two-factor partial least-squares regression model. (C) 2004 Society of Photo-Optical Instrumentation Engineers.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Industriell bioteknik -- Bioteknisk apparatteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Industrial Biotechnology -- Bioengineering Equipment (hsv//eng)

Nyckelord

online

dialysis

spectroscopy

dual-beam

near-infrared

urea

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)