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Birthweight is asso...
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Hansen, Aleksander L.Aarhus University Hospital,Steno Diabetes Center Copenhagen
(författare)
Birthweight is associated with clinical characteristics in people with recently diagnosed type 2 diabetes
- Artikel/kapitelEngelska2023
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:8537a016-e6d0-4fb4-a182-01e20ab87390
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https://lup.lub.lu.se/record/8537a016-e6d0-4fb4-a182-01e20ab87390URI
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https://doi.org/10.1007/s00125-023-05936-1DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes but it is unknown whether low birthweight is associated with distinct clinical characteristics at disease onset. We examined whether a lower or higher birthweight in type 2 diabetes is associated with clinically relevant characteristics at disease onset. Methods: Midwife records were traced for 6866 individuals with type 2 diabetes in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. Using a cross-sectional design, we assessed age at diagnosis, anthropomorphic measures, comorbidities, medications, metabolic variables and family history of type 2 diabetes in individuals with the lowest 25% of birthweight (<3000 g) and highest 25% of birthweight (>3700 g), compared with a birthweight of 3000–3700 g as reference, using log-binomial and Poisson regression. Continuous relationships across the entire birthweight spectrum were assessed with linear and restricted cubic spline regression. Weighted polygenic scores (PS) for type 2 diabetes and birthweight were calculated to assess the impact of genetic predispositions. Results: Each 1000 g decrease in birthweight was associated with a 3.3 year (95% CI 2.9, 3.8) younger age of diabetes onset, 1.5 kg/m2 (95% CI 1.2, 1.7) lower BMI and 3.9 cm (95% CI 3.3, 4.5) smaller waist circumference. Compared with the reference birthweight, a birthweight of <3000 g was associated with more overall comorbidity (prevalence ratio [PR] for Charlson Comorbidity Index Score ≥3 was 1.36 [95% CI 1.07, 1.73]), having a systolic BP ≥155 mmHg (PR 1.26 [95% CI 0.99, 1.59]), lower prevalence of diabetes-associated neurological disease, less likelihood of family history of type 2 diabetes, use of three or more glucose-lowering drugs (PR 1.33 [95% CI 1.06, 1.65]) and use of three or more antihypertensive drugs (PR 1.09 [95% CI 0.99, 1.20]). Clinically defined low birthweight (<2500 g) yielded stronger associations. Most associations between birthweight and clinical characteristics appeared linear, and a higher birthweight was associated with characteristics mirroring lower birthweight in opposite directions. Results were robust to adjustments for PS representing weighted genetic predisposition for type 2 diabetes and birthweight. Conclusion/interpretation: Despite younger age at diagnosis, and fewer individuals with obesity and family history of type 2 diabetes, a birthweight <3000 g was associated with more comorbidities, including a higher systolic BP, as well as with greater use of glucose-lowering and antihypertensive medications, in individuals with recently diagnosed type 2 diabetes.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Thomsen, Reimar W.Aarhus University Hospital
(författare)
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Brøns, CharlotteSteno Diabetes Center Copenhagen(Swepub:lu)ch8338br
(författare)
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Svane, Helene M.L.Aarhus University Hospital
(författare)
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Jensen, Rasmus T.University of Copenhagen
(författare)
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Andersen, Mette K.University of Copenhagen
(författare)
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Hansen, TorbenUniversity of Copenhagen
(författare)
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Nielsen, Jens S.Odense University Hospital
(författare)
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Vestergaard, PeterAalborg University Hospital
(författare)
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Højlund, KurtOdense University Hospital
(författare)
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Jessen, NielsSteno Diabetes Center Copenhagen
(författare)
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Olsen, Michael H.Holbæk Hospital,University of Southern Denmark
(författare)
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Sørensen, Henrik T.Aarhus University Hospital
(författare)
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Vaag, Allan A.Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,Steno Diabetes Center Copenhagen(Swepub:lu)med-ava
(författare)
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Aarhus University HospitalSteno Diabetes Center Copenhagen
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetologia66:9, s. 1680-16920012-186X
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Hansen, Aleksand ...
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Thomsen, Reimar ...
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Brøns, Charlotte
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Svane, Helene M. ...
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Jensen, Rasmus T ...
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Andersen, Mette ...
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visa fler...
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Hansen, Torben
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Nielsen, Jens S.
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Vestergaard, Pet ...
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Højlund, Kurt
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Jessen, Niels
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Olsen, Michael H ...
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Sørensen, Henrik ...
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Vaag, Allan A.
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Diabetologia
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